Transoral laser microsurgery for treatment of oropharyngeal cancer in 368 patients

Weiss, Bernhard G.; Ihler, Friedrich; Anczykowski, Mahalia Zoe; Bertlich, Mattis; Kitz, Julia; Steiner, Wolfgang; Canis, Martin und Jakob, Mark (2019): Transoral laser microsurgery for treatment of oropharyngeal cancer in 368 patients. In: Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, Bd. 41, Nr. 9: S. 3144-3158

Abstract

Background Oncological and functional outcome of transoral laser microsurgery (TLM) for primary treatment of oropharyngeal cancer was examined using a multimodal treatment concept. Methods A total of 368 patients with oropharyngeal squamous cell carcinoma (pT1-4, pN0-2, M0) underwent TLM +/- neck dissection (85%), +/- (chemo)radiotherapy (57%). The majority of patients had advanced stage III and IVa disease (79%). Results Five-year Kaplan-Meier estimates for local control were 83.5% for pT1, 74.1% for pT2, 77.3% for pT3, and 76.0% for pT4a tumors. Five-year estimates of overall, disease-specific, and recurrence-free survival for stage I were 76.0%, 92.8%, and 69.1%;for stage II 71.1%, 85.7%, and 49.6%;for stage III 61.7%, 72.5%, and 58.8%;and for stage IVa 57.3%, 73.7%, and 63.9%, respectively. Postoperative (chemo)radiotherapy improved the outcome for advanced disease. p16-positive tumors had superior survival estimates. Overall, 93.5% maintained regular oral nutrition without feeding tube dependency. Conclusion Primary TLM in multimodal concepts of treatment offers good oncologic outcome even for advanced-stage oropharyngeal cancer.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1043-3074
• Sprache: Englisch