Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

Lamort, Anne-Sophie; Giopanou, Ioanna; Psallidas, Ioannis und Stathopoulos, Georgios T. (2019): Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight. In: Cells, Bd. 8, Nr. 8, 815

Abstract

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch