Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs?

Busygina, Kristina; Denzinger, Viola; Bernlochner, Isabell; Weber, Christian; Lorenz, Reinhard und Siess, Wolfgang (2019): Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs? In: Thrombosis and Haemostasis, Bd. 119, Nr. 8: S. 1212-1221

Abstract

Bruton's tyrosine kinase (Btk) is essential for B cell differentiation and proliferation, but also platelets express Btk. Patients with X-linked agammaglobulinemia due to hereditary Btk deficiency do not show bleeding, but a mild bleeding tendency is observed in high dose therapy of B-cell malignancies with ibrutinib and novel second-generation irreversible Btk inhibitors (acalabrutinib and ONO/GS-4059). This review discusses recent studies that may explain this apparent paradox and gives mechanistic insights that suggest a unique potential of low dose irreversible Btk inhibitors as atherothrombosis-focused antiplatelet drugs.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0340-6245
• Sprache: Englisch