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Riepl, Rudolf L.; Lehnert, Peter (1992): The Role of Bile in the Regulation of Exocrine Pancreatic Secretion. In: Scandinavian Journal of Gastroenterology, Vol. 26, No. 8: pp. 625-631


As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice. In conscious dogs, Ivy & Lueth (2) reported, bile is only a weak stimulant of pancreatic secretion. Diversion of bile from the duodenum, however, did not influence pancreatic volume secretion stimulated by a meal (3,4). Moreover, Thomas & Crider (5) observed that bile not only failed to stimulate the secretion of pancreatic juice but also abolished the pancreatic response to intraduodenally administered peptone or soap.