Suicidality and risk of suicidality in psoriasis: a critical appraisal of two systematic reviews and meta-analyses

Matterne, U.; Baumeister, S. E. und Apfelbacher, C. J. (2019): Suicidality and risk of suicidality in psoriasis: a critical appraisal of two systematic reviews and meta-analyses. In: British Journal of Dermatology, Bd. 181, Nr. 4: S. 717-721

Abstract

Aim Chi et al.(1) and Singh et al.(2) each conducted a systematic review and meta-analysis of observational studies examining the relationship between suicidality and psoriasis. Setting and design Chi et al. included only cohort studies while Singh et al. included cohort, cross-sectional and case-control studies. Primary exposure and outcome The primary outcome, suicidality, was assessed in people with psoriasis (exposure) and people without psoriasis. Analyses were separated for suicidal ideation and behaviour. Results Chi et al. included five population-based cohort studies that were considered to be of high quality according to the Newcastle-Ottawa Scale (NOS). They found no significant increase in the risk of suicide [risk ratio (RR) 1 center dot 13, 95% confidence interval (CI) 0 center dot 87-1 center dot 46], suicide attempt (RR 1 center dot 25, 95% CI 0 center dot 89-1 center dot 75) or suicidality (RR 1 center dot 26, 95% CI 0 center dot 97-1 center dot 64) among people with psoriasis. Singh et al. included 18 studies that were rated to be of medium quality to high quality according to the NOS. They found a pooled odds ratio (OR) of 2 center dot 05 (95% CI 1 center dot 54-2 center dot 74) for suicidal ideation among patients with psoriasis. For suicidal behaviours (combined attempted and completed suicides) a pooled OR of 1 center dot 26 (95% CI 1 center dot 13-1 center dot 40) was obtained, suggesting a higher risk of these behaviours in people with psoriasis. Subgroup analysis showed that patients with psoriasis were more likely to attempt suicide (OR 1 center dot 32, 95% CI 1 center dot 14-1 center dot 54) and complete suicide (OR 1 center dot 20, 95% CI 1 center dot 04-1 center dot 39) than those without psoriasis. Conclusions Singh et al. concluded that patients with psoriasis have a significantly higher risk of suicidal ideation, suicide attempts and completed suicides, while Chi et al. concluded that the available, limited, very low-quality evidence does not support the notion of an association between psoriasis on the one hand, and suicide, suicidal ideation and suicide attempts on the other.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0007-0963
• Sprache: Englisch