Edge-to-Edge Mitral Valve Repair With Extended Clip Arms Early Experience From a Multicenter Observational Study

Praz, Fabien; Braun, Daniel; Unterhuber, Matthias; Spirito, Alessandro; Orban, Mathias; Brugger, Nicolas; Brinkmann, Isabel; Spring, Karin; Moschovitis, Aris; Nabauer, Michael; Blazek, Stephan; Pilgrim, Thomas; Thiele, Holger; Lurz, Philipp; Hausleiter, Jörg und Windecker, Stephan (2019): Edge-to-Edge Mitral Valve Repair With Extended Clip Arms Early Experience From a Multicenter Observational Study. In: Jacc-Cardiovascular Interventions, Bd. 12, Nr. 14: S. 1356-1365

Abstract

OBJECTIVES The aim of this study was to investigate the technical success and efficacy of mitral valve edge-to-edge repair using extended clip arms. BACKGROUND A new iteration of the MitraClip system, the MitraClip XTR, was introduced in 2018 with the aim of addressing technical limitations observed with previous versions. METHODS Patients having received at least 1 new implant for the treatment of symptomatic mitral regurgitation (MR) were eligible for this study. RESULTS Among the 107 patients (mean age 76 +/- 9 years, 69% men) included in this study, the etiology of MR was balanced, with one-half (n = 53 [50%]) classified as secondary and the remaining 54 patients having either primary (n = 40 [37%]) or mixed (n = 14 [13%]) disease. The mean number of devices implanted was 1.5 +/- 0.6. Multiple device implantation was required in 46 patients (43%). Single-leaflet device attachment occurred in 4 patients and leaflet injury in 2 additional patients, requiring surgical conversion in 4 patients. Among the 102 patients discharged alive without mitral valve surgery, 95 (93%) had MR <= 2+ and 79 (77%) had MR <= 1+. The mean transmitral gradient increased from 1.9 +/- 1.0 mm Hg at baseline to 3.5 +/- 1.8 mm Hg at discharge (p < 0.001). CONCLUSIONS Technical success with the new mitral valve repair system with extended clip arm was achieved in 93% of the patients. MR <= 2+ was obtained in 95 patients (93%) and MR <= 1+ in 79 (77%). The main reasons for procedural failure were acute single-leaflet device attachment associated with leaflet damage or isolated leaflet injury and often required surgical correction. (C) 2019 by the American College of Cardiology Foundation.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1936-8798
• Sprache: Englisch