Gastrointestinale Beschwerden unter Apremilast. Charakterisierung und Management

Pinter, Andreas; Beigel, Florian; Koerber, Andreas; Homey, Bernhard; Beissert, Stefan; Gerdes, Sascha; Staubach-Renz, Petra; Radtke, Marc-Alexander und Moessner, Rotraut (2019): Gastrointestinale Beschwerden unter Apremilast. Charakterisierung und Management. In: Hautarzt, Bd. 70, Nr. 5: S. 354-361

Abstract

Apremilast is an oral inhibitor of phosphodiesterase-4 (PDE4) that is licensed for the second-line treatment of psoriasis and psoriatic arthritis. Data from several phaseIII clinical trials and real-world studies showed agood benefit-risk profile, with diarrhea and nausea as the most common adverse events. Diarrhea and nausea most frequently occurred during the first month of treatment. In most cases, they were mild or moderate in severity and tended to resolve over time with continued dosing and without intervention. In this review we summarize available data on gastrointestinal side effects of apremilast in patients with psoriasis and psoriasis arthritis and provide practical strategies for managing these symptoms.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0017-8470
• Sprache: Deutsch