Darmmikrobiom und chronisch-entzündliche Darmerkrankungen

Schwerd, T. und Koletzko, S. (2019): Darmmikrobiom und chronisch-entzündliche Darmerkrankungen. In: Monatsschrift Kinderheilkunde, Bd. 167, Nr. 5: S. 420-425

Abstract

The gut microbiota is thought to influence the development and progression of chronic inflammatory bowel disease (IBD) but the mechanisms are only partly understood. In IBD, intestinal dysbiosis occurs that is characterized by altered structure and function of the microbial community. These microbiota changes can serve as diagnostic and predictive biomarkers. A therapeutic modification of gut dysbiosis, e.g. by diet, antibiotics or fecal microbiota transplantation (FMT) could be anovel treatment strategy in patients with IBD. Although FMT is a highly effective treatment for recurrent Clostridium difficile infections, the efficacy of FMT bacteriotherapy for treating IBD-associated microbial dysbiosis is so far not very convincing with ahigh variability in patient response.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0026-9298
• Sprache: Deutsch