Surviving Acute Organ Failure: Cell Polyploidization and Progenitor Proliferation

Lazzeri, Elena; Angelotti, Maria Lucia; Conte, Carolina; Anders, Hans-Joachim und Romagnani, Paola (2019): Surviving Acute Organ Failure: Cell Polyploidization and Progenitor Proliferation. In: Trends in Molecular Medicine, Bd. 25, Nr. 5: S. 366-381

Abstract

In acute organ failure, rapid compensation of function loss assures survival. Dedifferentiation and/or proliferation of surviving parenchymal cells could imply a transient (and potentially fatal) impairment of residual functional performance. However, evolution has selected two flexible life-saving mechanisms acting synergistically on organ function recovery. Sustaining residual performance is possible when the remnant differentiated parenchymal cells avoid cell division, but increase function by undergoing hypertrophy via endoreplication, leading to polyploid cells. In addition, tissue progenitors, representing a subset of less-differentiated and/or self-renewing parenchymal cells completing cytokinesis, proliferate and differentiate to regenerate lost parenchymal cells. Here, we review the evolving evidence on polyploidization and progenitor-driven regeneration in acute liver, heart, and kidney failure with evolutionary advantages and trade-offs in organ repair.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1471-4914
• Sprache: Englisch