Differential prognostic relevance of patho-anatomical factors among different tumor-biological subsets of breast cancer: Results from the adjuvant SUCCESS A study

Deniz, Miriam; DeGregorio, Amelie; DeGregorio, Nikolaus; Bekes, Inga; Widschwendter, Peter; Schochter, Fabienne; Ernst, Kristina; Scholz, Christoph; Bauer, Emanuel C. A.; Aivazova-Fuchs, Viktoria; Weissenbacher, Tobias; Kost, Bernd; Jueckstock, Julia; Andergassen, Ullrich; Steidl, Julia; Trapp, Elisabeth; Fasching, Peter A.; Haeberle, Lothar; Beckmann, Matthias W.; Schneeweiss, Andreas; Schrader, Iris; Janni, Wolfgang; Rack, Brigitte und Friedl, Thomas W. P. (2019): Differential prognostic relevance of patho-anatomical factors among different tumor-biological subsets of breast cancer: Results from the adjuvant SUCCESS A study. In: Breast, Bd. 44: S. 81-89

Abstract

Objectives: In breast cancer, large tumor size, positive nodal stage and a triple-negative tumor subtype are associated with reduced survival, but the interactions between these prognostic factors are not well understood. Material and methods: Here we re-evaluated the impact of tumor size, nodal stage and tumor subtype on disease-free survival (DFS), overall survival (OS), distant disease-free survival (DDFS) and breast cancer specific survival (BCSS) in a retrospective analysis using data from the adjuvant SUCCESS A trial. Subgroup analyses were conducted to assess whether the effect of tumor size and nodal stage on survival depended on tumor subtype. Results: Increasing tumor size, higher nodal stage and triple negative breast cancer (TNBC) were associated with unfavorable prognosis (all p <0.001). There was no significant interaction between tumor subtype and tumor size (p > 0.5 for all four survival endpoints), but we found significant interactions between tumor subtype and nodal stage (p <0.05 for all four survival endpoints), with no differences in survival among tumor subtypes for patients with pN0 tumors (all p> 0.05) and pronounced differences in survival among tumor subtypes for patients with positive nodal stage (all p <0.001). Conclusions: This analysis confirms tumor size, nodal stage and tumor subtype as independent prognostic factors in high-risk early breast cancer. Nodal-positive patients with TNBC had a considerably worse outcome compared to nodal-positive patients with another tumor subtype. This underlines the importance for early detection particularly for patients with TNBC. (C) 2019 Elsevier Ltd. All rights reserved.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0960-9776
• Sprache: Englisch