Poetsch, Joseph H.; Dahlke, Christine; Zinser, Madeleine E.; Kasonta, Rahel; Lunemann, Sebastian; Rechtien, Anne; Ly, My L.; Stubbe, Hans C.; Kraehling, Verena; Biedenkopf, Nadine; Eickmann, Markus; Fehling, Sarah K.; Olearo, Flaminia; Strecker, Thomas; Sharma, Piyush; Lang, Karl S.; Lohse, Ansgar W.; Schmiedel, Stefan; Becker, Stephan; Siegrist, Claire-Anne; Huttner, Angela; Addo, Marylyn M.; Bejon, Phillip; Njuguna, Patricia; Ndungu, Francis; Kremsner, Peter G.; Brosnahan, Jessica S.; Agnandji, Selidji Todagbe; Krishna, Sanjeev; Kieny, Marie Paule; Modjarrad, Kayvon; Moorthy, Vasee; Fast, Patricia; Savarese, Barbara; Lapujade, Olivier (2019): Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans. In: Journal of Infectious Diseases, Vol. 219, No. 4: pp. 556-561 |
Abstract
In response to the Ebola virus (EBOV) crisis of 2013-2016, a recombinant vesicular stomatitis virus (VSV)-based EBOV vaccine was clinically tested (NCT02283099). A single-dose regimen of VSV-EBOV revealed a safe and immunogenic profile and demonstrated clinical efficacy. While EBOV-specific immune responses to this candidate vaccine have previously been investigated, limited human data on immunity to the VSV vector are available. Within the scope of a phase 1 study, we performed a comprehensive longitudinal analysis of adaptive immune responses to internal VSV proteins following VSV-EBOV immunization. While no preexisting immunity to the vector was observed, more than one-third of subjects developed VSV-specific cytotoxic T-lymphocyte responses and antibodies.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0022-1899 |
Language: | English |
ID Code: | 80480 |
Deposited On: | 15. Dec 2021 14:53 |
Last Modified: | 15. Dec 2021 14:53 |
- BASE
- Poetsch, Joseph H.
- Dahlke, Christine
- Zinser, Madeleine E.
- Kasonta, Rahel
- Lunemann, Sebastian
- Rechtien, Anne
- Ly, My L.
- Stubbe, Hans C.
- Kraehling, Verena
- Biedenkopf, Nadine
- Eickmann, Markus
- Fehling, Sarah K.
- Olearo, Flaminia
- Strecker, Thomas
- Sharma, Piyush
- Lang, Karl S.
- Lohse, Ansgar W.
- Schmiedel, Stefan
- Becker, Stephan
- Siegrist, Claire-Anne
- Huttner, Angela
- Addo, Marylyn M.
- Bejon, Phillip
- Njuguna, Patricia
- Ndungu, Francis
- Kremsner, Peter G.
- Brosnahan, Jessica S.
- Agnandji, Selidji Todagbe
- Krishna, Sanjeev
- Kieny, Marie Paule
- Modjarrad, Kayvon
- Moorthy, Vasee
- Fast, Patricia
- Savarese, Barbara
- Lapujade, Olivier
- Google Scholar
- Poetsch, Joseph H.
- Dahlke, Christine
- Zinser, Madeleine E.
- Kasonta, Rahel
- Lunemann, Sebastian
- Rechtien, Anne
- Ly, My L.
- Stubbe, Hans C.
- Kraehling, Verena
- Biedenkopf, Nadine
- Eickmann, Markus
- Fehling, Sarah K.
- Olearo, Flaminia
- Strecker, Thomas
- Sharma, Piyush
- Lang, Karl S.
- Lohse, Ansgar W.
- Schmiedel, Stefan
- Becker, Stephan
- Siegrist, Claire-Anne
- Huttner, Angela
- Addo, Marylyn M.
- Bejon, Phillip
- Njuguna, Patricia
- Ndungu, Francis
- Kremsner, Peter G.
- Brosnahan, Jessica S.
- Agnandji, Selidji Todagbe
- Krishna, Sanjeev
- Kieny, Marie Paule
- Modjarrad, Kayvon
- Moorthy, Vasee
- Fast, Patricia
- Savarese, Barbara
- Lapujade, Olivier