To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps

Boeltz, Sebastian; Amini, Poorya; Anders, Hans-Joachim; Andrade, Felipe; Bilyy, Rostyslav; Chatfield, Simon; Cichon, Iwona; Clancy, Danielle M.; Desai, Jyaysi; Dumych, Tetiana; Dwivedi, Nishant; Gordon, Rachael Ann; Hahn, Jonas; Hidalgo, Andres; Hoffmann, Markus H.; Kaplan, Mariana J.; Knight, Jason S.; Kolaczkowska, Elzbieta; Kubes, Paul; Leppkes, Moritz; Manfredi, Angelo A.; Martin, Seamus J.; Maueroder, Christian; Maugeri, Norma; Mitroulis, Ioannis; Munoz, Luis E.; Nakazawa, Daigo; Neeli, Indira; Nizet, Victor; Pieterse, Elmar; Radic, Marko Z.; Reinwald, Christiane; Ritis, Konstantinos; Rovere-Querini, Patrizia; Santocki, Michal; Schauer, Christine; Schett, Georg; Shlomchik, Mark Jay; Simon, Hans-Uwe; Skendros, Panagiotis; Stojkov, Darko; Vandenabeele, Peter; Vanden Berghe, Tom; Vlag, Johan van der; Vitkov, Ljubomir; Koeckritz-Blickwede, Maren von; Yousefi, Shida; Zarbock, Alexander und Herrmann, Martin (2019): To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps. In: Cell Death and Differentiation, Bd. 26, Nr. 3: S. 395-408

Abstract

Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1350-9047
• Sprache: Englisch