Potassium channels in omnipause neurons

Mayadali, Umit S.; Lienbacher, Karoline; Mustari, Michael; Strupp, Michael und Horn, Anja K. E. (2019): Potassium channels in omnipause neurons. In: Mathematical Modelling in Motor Neuroscience: State of the Art and Translation To the Clinic. Gaze Orienting Mechanisms and Disease, Bd. 249: S. 117-123

Abstract

Potassium (K+) channels are major contributors to fast and precise action potential generation. The aim of this study was to establish the immunoreactivity profile of several potassium channels in omnipause neurons (OPNs), which play a central role in premotor saccadic circuitry. To accomplish this, we histochemically examined monkey and human brainstem sections using antibodies against the voltage gated K+-channels K(V)1.1, K(V)3.1b and K+-Cl- cotransporter (KCC2). We found that OPNs of both species were positive for all three K+-antibodies and that the staining patterns were similar for both species. In individual OPNs, K(V)3.1b was detected on the somatic membrane and proximal dendrites, while KV1.1 was mainly confined to soma. Further, KCC2 immunoreactivity was strong in distal dendrites, but was weak in the somatic membrane. Our findings allow the speculation that the alterations in K+-channel expression in OPNs could be the underlying mechanism for several saccadic disorders through neuronal and circuit-level malfunction.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0079-6123
• Sprache: Englisch