Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease

Grimmer, Timo; Goldhardt, Oliver; Yakushev, Igor; Ortner, Marion; Sorg, Christian; Diehl-Schmid, Janine; Foerstl, Hans; Kurz, Alexander; Perneczky, Robert and Miners, Scott (2019): Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease. In: Neurodegenerative Diseases, Vol. 19, No. 1: pp. 43-50

Abstract

Background: Neprilysin (NEP) cleaves amyloid-beta 1-42 (A beta(42)) in the brain. Hence, we aimed to elucidate the effect of NEP on A beta(42) in cerebrospinal fluid (CSF) and on in vivo brain amyloid load using amyloid positron emission tomography (PET) with [C-11]PiB (Pittsburgh compound B). In addition, associations with the biomarkers for neuronal injury, CSF-tau and FDG-PET, were investigated. Methods: Associations were calculated using global and voxel-based (SPM8) linear regression analyses in the same cohort of 23 highly characterized Alzheimer's disease patients. Results: CSF-NEP was significantly inversely associated with CSF-A beta(42) and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET. Conclusions: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer's pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration. (C) 2019 S. Karger AG, Basel

• Item Type: Journal article
• Faculties: Medicine
• Subjects: 600 Technology > 610 Medicine and health
• ISSN: 1660-2854
• Language: English