Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease

Brugnolo, Andrea; De Carli, Fabrizio; Pagani, Marco; Morbelli, Slivia; Jonsson, Cathrine; Chincarini, Andrea; Frisoni, Giovanni B.; Galluzzi, Samantha; Perneczky, Robert; Drzezga, Alexander; van Berckel, Bart N. M.; Ossenkoppele, Rik; Didic, Mira; Guedj, Eric; Arnaldi, Dario; Massa, Federico; Grazzini, Matteo; Pardini, Matteo; Mecocci, Patrizia; Dottorini, Massimo E.; Bauckneht, Matteo; Sambuceti, Gianmario und Nobili, Flavio (2019): Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease. In: Journal of Alzheimers Disease, Bd. 68, Nr. 1: S. 383-394

Abstract

Background: Several automatic tools have been implemented for semi-quantitative assessment of brain [(18)]F-FDG-PET. Objective: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e., PALZ), and a volumetric region of interest (VROI-SVM)-based approach, in distinguishing patients with prodromal Alzheimer's disease (pAD) from controls. Methods: Sixty-two pAD patients (MMSE score = 27.0 +/- 1.6) and one hundred-nine healthy subjects (CTR) (MMSE score = 29.2 +/- 1.2) were enrolled in five centers of the European Alzheimer's Disease Consortium. The three SPM-based methods, based on different rationales, included 1) a cluster identified through the correlation analysis between [(18)]F-FDG-PET and a verbal memory test (VROI-1), 2) a VROI derived from the comparison between pAD and CTR (VROI-2), and 3) visual analysis of individual maps obtained by the comparison between each subject and CTR (SPM-Maps). The VROI-SVM approach was based on 6 VROI plus 6 VROI asymmetry values derived from the pAD versus CTR comparison thanks to support vector machine (SVM). Results: The areas under the ROC curves between pAD and CTR were 0.84 for VROI-1, 0.83 for VROI-2, 0.79 for SPM maps, 0.87 for PALZ, and 0.95 for VROI-SVM. Pairwise comparisons of Youden index did not show statistically significant differences in diagnostic performance between VROI-1, VROI-2, SPM-Maps, and PALZ score whereas VROI-SVM performed significantly (p < 0.005) better than any of the other methods. Conclusion: The study confirms the good accuracy of [(18)]F-FDG-PET in discriminating healthy subjects from pAD and highlights that a non-linear, automatic VROI classifier based on SVM performs better than the voxel-based methods.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1387-2877
• Sprache: Englisch