Abstract
BackgroundUrinary involvement is common in hereditary spastic paraplegias (HSPs), but has rarely been assessed systematically.MethodsWe characterized urinary complaints in 71 German HSP patients (mean age 55.413.9years;mean disease duration 20.714.3years;48% SPG4-positive) using validated clinical rating scales (SCOPA-AUT, ICIQ-SF, ICIQ-LUTSqol). Treatment history and satisfaction with medical care was also assessed.Results p id=Par3 74.6% of patients had one or more urological problems, most commonly nocturia and urgency. Incontinence was more severe in women, correlating with SCOPA-AUT. Female gender and SPG4 mutations were associated with higher urinary frequency and severity of urological involvement. QoL was overall reduced, more in women and in SPG4 mutation carriers. Almost 90% consulted a medical specialist;more than half were largely satisfied. 43.4% received oral medication and 5.7% received intravesical botulinum toxin. However, more than one-third of patients remained untreated.Conclusion p id=Par4 Urinary complaints are common in HSP and should be addressed and treated.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0340-5354 |
Language: | English |
Item ID: | 80893 |
Date Deposited: | 15. Dec 2021, 14:55 |
Last Modified: | 15. Dec 2021, 14:55 |