Urinary symptoms, quality of life, and patient satisfaction in genetic and sporadic hereditary spastic paraplegia

Schneider, Susanne A.; Beckinger, Viktoria E.; Moeller, Bettina; Knuepfer, Stephanie; Hamann, Moritz und Deuschl, Guenther (2019): Urinary symptoms, quality of life, and patient satisfaction in genetic and sporadic hereditary spastic paraplegia. In: Journal of Neurology, Bd. 266, Nr. 1: S. 207-211

Abstract

BackgroundUrinary involvement is common in hereditary spastic paraplegias (HSPs), but has rarely been assessed systematically.MethodsWe characterized urinary complaints in 71 German HSP patients (mean age 55.413.9years;mean disease duration 20.714.3years;48% SPG4-positive) using validated clinical rating scales (SCOPA-AUT, ICIQ-SF, ICIQ-LUTSqol). Treatment history and satisfaction with medical care was also assessed.Results p id=Par3 74.6% of patients had one or more urological problems, most commonly nocturia and urgency. Incontinence was more severe in women, correlating with SCOPA-AUT. Female gender and SPG4 mutations were associated with higher urinary frequency and severity of urological involvement. QoL was overall reduced, more in women and in SPG4 mutation carriers. Almost 90% consulted a medical specialist;more than half were largely satisfied. 43.4% received oral medication and 5.7% received intravesical botulinum toxin. However, more than one-third of patients remained untreated.Conclusion p id=Par4 Urinary complaints are common in HSP and should be addressed and treated.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0340-5354
• Sprache: Englisch