Logo Logo
Help
Contact
Switch Language to German

Aoki, R.; Clanner-Engelshofen, B. M.; Charnowski, S.; Ruzicka, T. and Reinholz, M. (2019): Distribution of high-risk alpha-genus human papillomavirus genotypes impacts cutaneous neoplasms. In: Journal of the European Academy of Dermatology and Venereology, Vol. 33, No. 7: pp. 1304-1311

Full text not available from 'Open Access LMU'.

Abstract

Background High-risk alpha-genus human papillomaviruses (alpha-HPVs) are linked to cervical and genital carcinomas;however, their correlation with cutaneous squamous cell carcinoma (cuSCC) or premalignant skin lesions remains controversial. Objective We evaluated the contribution of high-risk alpha-HPV to the occurrence of cuSCC, Bowen's disease and actinic keratosis (AK), and the distribution of high-risk alpha-HPV genotypes in these cutaneous tumours. Methods HPV genotypes were determined using a commercial PCR-based microarray on skin tissue samples collected from 76 [38 young (<60 years) and 38 elderly (>60 years)] cuSCC, 34 Bowen's disease, 48 AK patients and 10 young controls. Associations between alpha-HPV prevalence and relevant risk factors were analysed. Results High-risk alpha-HPV was more frequently detected in cuSCC patients (57.9%) than in the patients with Bowen's disease (38.2%), AK (0.0%) and control patients (10.0%). The high-risk alpha-HPV prevalence was higher in young than in elderly cuSCC patients (65.8% vs. 50.0%, P = 0.031). The most common HPV type was 16, present in 90.9% of all HPV-carrying cuSCC patients. Multiple infections with different high-risk alpha-HPV types were found in 20.5% of HPV-related cuSCC, whereas only single infection with type 16 was found in Bowen's disease. Although sun exposure is known as a major risk factor for cuSCC, high-risk alpha-HPVs were more frequently found in non-exposed sites rather than in sun-exposed sites of cuSCC. Conclusion Multiple infections, as well as single infection with high-risk alpha-HPV may link to cuSCC. In spite of the involvement of high-risk alpha-HPV at high levels in cuSCC and Bowen's disease, no high-risk alpha-HPV was detected in AK patients, suggesting that Bowen's disease rather than AK might be involved in the development of HPV-related cuSCC as a precursor.

Actions (login required)

View Item View Item