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Roest, Annelieke M.; de Vries, Ymkje Anna; Lim, Carmen C. W.; Wittchen, Hans-Ulrich; Stein, Dan J.; Adamowski, Tomasz; Al-Hamzawi, Ali; Bromet, Evelyn J.; Viana, Maria Carmen; de Girolamo, Giovanni; Demyttenaere, Koen; Florescu, Silvia; Gureje, Oye; Maria Haro, Josep; Hu, Chiyi; Karam, Elie G.; Caldas-de-Almeida, Jose Miguel; Kawakami, Norito; Lepine, Jean Pierre; Levinson, Daphna; Medina-Mora, Maria E.; Navarro-Mateu, Fernando; O'Neill, Siobhan; Piazza, Marina; Posada-Villa, Jose A.; Slade, Tim; Torres, Yolanda; Kessler, Ronald C.; Scott, Kate M. and de Jonge, Peter (2019): A comparison of DSM-5 and DSM-IV agoraphobia in the World Mental Health Surveys. In: Depression and Anxiety, Vol. 36, No. 6: pp. 499-510

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Abstract

Background The Diagnostic and Statistical Manual of Mental Disorders, version 5 (DSM-5) definition of agoraphobia (AG) as an independent diagnostic entity makes it timely to re-examine the epidemiology of AG. Study objective was to present representative data on the characteristics of individuals who meet DSM-IV criteria for AG (AG without a history of panic disorder [PD] and PD with AG) but not DSM-5 criteria, DSM-5 but not DSM-IV criteria, or both sets of criteria. Methods Population-based surveys from the World Mental Health Survey Initiative including adult respondents (n = 136,357) from 27 countries across the world. The Composite International Diagnostic Interview was used to assess AG and other disorders. Results Lifetime and 12-month prevalence estimates of DSM-5 AG (1.5% and 1.0%) were comparable to DSM-IV (1.4% and 0.9%). Of respondents meeting criteria in either system, 57.1% met criteria in both, while 24.2% met criteria for DSM-5 only and 18.8% for DSM-IV only. Severe role impairment due to AG was reported by a lower proportion of respondents who met criteria only for DSM-IV AG (30.4%) than those with both DSM-5 and DSM-IV AG (44.0%;chi(2)(1) = 4.7;P = 0.031). The proportion of cases with any comorbidity was lower among respondents who met criteria only for DSM-IV AG (78.7%) than those who met both sets (92.9%;chi(2)(1)= 14.5;P < 0.001). Conclusions This first large survey shows that, compared to the DSM-IV, the DSM-5 identifies a substantial group of new cases with AG, while the prevalence rate remains stable at 1.5%. Severity and comorbidity are higher in individuals meeting DSM-5 AG criteria compared with individuals meeting DSM-IV AG criteria only.

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