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Abtan, Jeremie; Ducrocq, Gregory; Steg, Ph Gabriel; Stone, Gregg W.; Mahaffey, Kenneth W.; Gibson, C. Michael; Hamm, Christian; Price, Matthew J.; Prats, Jayne; Elkin, Steven; Deliargyris, Efthymios N.; White, Harvey D.; Menozzi, Alberto; Harrington, Robert A.; Bhatt, Deepak L.; Benzer, Werner; Delle-Karth, Georg; Huber, Kurt; Leisch, Franz; Saad, Jamil Abdalla; Abizaid, Alexandre; Formiga Areas, Carlos Augusto; Ribeiro, Expedito E.; Dos Santos, Fabio Rossi; Tumelero, Rogerio Tadeu; Botelho, Roberto Vieira; Atzev, Borislav; Boichev, Boicho; Grigorov, Georgi; Penkov, Nikolay; Petrov, Ivo; Zehirov, Boris; Cervinka, Pavel; Coufal, Zdenek; Hajek, Petr; Horak, David; Kala, Petr; Kmonicek, Petr; Kocka, Viktor; Mrozek, Jan; Simek, Stanislav; Sitar, Jan; Stasek, Josef; Tousek, Frantisek; Chapidze, Gulnara; Emukhvari, Nodar; Khabeishvili, George; Mamatsashvili, Merab; Shaburishvili, Tamaz; Behrens, Steffen; Darius, Harald; Dissmann, Martin; Fichtlscherer, Stephan; Franz, Wolfgang; Geisler, Tobias; Genth-Zotz, Sabine; Goldmann, Britta; Heuer, Hubertus; Hoffmann, Stefan; Mugge, Andreas; Poerner, Tudor; Radke, Peter; Richardt, Gert; Stellbrink, Christoph; Werner, Nikos; Bramucci, Ezio; De Servi, Stefano; Galasso, Gennaro; Musumeci, Giuseppe; Picchi, Andrea; Presbitero, Patrizia; Devlin, Gerard; Sasse, Alexander; Scott, Douglas; Stewart, Ralph; Andrzej, Szyszka; Dubaniewicz, Witold; Gasior, Zbigniew; Kasprzak, Jaroslaw; Kleinrok, Andrzej; Kornacewicz-Jach, Zdzislawa; Rynkiewicz, Andrzej; Sosnowski, Cezary; Targonski, Radoslaw; Trebacz, Jaroslaw; Witkowski, Adam; Zinka, Elzbieta; Barbarash, Olga; Dovgalevsky, Yakov; Gordeev, Ivan; Kalinina, Svetlana; Kosmachova, Elena; Linev, Kirill; Markov, Valentin; Pavlov, Prokhor; Shalaev, Sergey; Shogenov, Zaur; Sukmanova, Irina; Vasilieva, Elena; Yakovlev, Alexey; Boonbaichaiyapruck, Sarana; Chamnarnphol, Noppadol; Kaewsuwanna, Pinij; Kuanprasert, Srun; Piyayotai, Dilok; Amine, Maged; Angiolillo, Dominick; Arif, Imran; Blankenship, James; Brilakis, Emmanouil; Chan, Michael; Cinderella, Joseph; Davis, Brent; Devireddy, Chandanreddy; Dorogy, Mark; Douglas, John; Ferrier, Norman; Fisher, Daniel; Foster, Robert; French, William; Galla, John; Gimple, Lawrence; Gogia, Harinder; Gogo, Prospero; Gollapudi, Raghava; Gruberg, Luis; Hermiller, James; Heuser, Richard; Iwaoka, Robert; Jafar, Zubair; Kimmelstiel, Carey; Kinlay, Scott; Leggett, James; Leimgruber, Pierre; Letts, Dustin; Lipsitt, Michael; Low, Reginald; Martinez-Arraras, Joaquin; Mayhew, Marc; McLaurin, Brent; McWhirter, Paul; Mirza, Ayoub; Negus, Brian; Nygaard, Thomas; O'Riordan, William; Paulus, Richard; Petersen, John; Picon, Hector; Picone, Mark; Price, Matthew; Rivera, Ernesto; Rizik, David; Rodriguez, Arsenio; Saucedo, Jörge; Scott, J. Christopher; Sethi, Virender; Shroff, Adhir; Siegel, Craig; Spriggs, Douglas; Steinberg, Daniel; Stillabower, Michael; Stuckey, Thomas; Suarez, Jose; Tauth, Jeffrey; Temizer, Dogan; Vidovich, Mladen; Voeltz, Michele; Waltman, Jonathan and Wilensky, Michael (2019): Characteristics and outcomes of patients requiring bailout use of glycoprotein IIb/IIIa inhibitors for thrombotic complications of percutaneous coronary intervention: An analysis from the CHAMPION PHOENIX trial. In: International Journal of Cardiology, Vol. 278: pp. 217-222

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Abstract

Aims: To describe the characteristics and outcomes of patients receiving bailout glycoprotein IIb/IIIa inhibitors (GPI) for thrombotic complications of percutaneous coronary intervention (PCI) in a large, contemporary trial. Methods and results: In the CHAMPIONPHOENIX trial, the use of GPIwas restricted to bailout for thrombotic complications. We describe the characteristics and outcomes of patients requiring bailout GPI compared to patients not receiving GPIs, with adjustment through propensity-score. A multivariablemodel was constructed to identify independent correlates associated with bailout GPI use. A total of 380 out of 10,942 patients received GPI (3.5%);GPI patientswere younger, more frequentlymale, more likely to present with ST segment elevation myocardial infarction and less frequently treated with cangrelor. At 48 h, GPI patients experienced higher rates of the primary composite outcome of death, myocardial infarction, ischemia-driven revascularization, or stent thrombosis (ST) (19.2% vs 4.8%;adjusted OR: 5.65(4.08, 7.82), p < 0.0001) and a higher rate of GUSTO severe or moderate bleeding (2.6% vs 0.4% adjusted OR: 4.90 (1.98, 12.18), p = 0.0006) compared with non GPI patients. Independent correlates of GPI use were STEMI, use of unfractionated heparin, drug-eluting stents and longer procedure duration. Conclusions: In a large contemporary trial, patients receiving bailout GPI for thrombotic complications of PCI experienced very high risks of both ischemic and bleeding complications, suggesting that prevention of periprocedural complications rather than bailout GPI may be preferable. Clinical Trial Registration: http://www.clinicaltrials.gov identifier: NCT01156571. (c) 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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