D-Dimer Predicts Disease Severity but Not Long-Term Prognosis in Acute Pulmonary Embolism

Geissenberger, Fabian; Schwarz, Florian; Probst, Michael; Haberl, Sabine; Gruetzner, Stefanie; Kroencke, Thomas; Scheidt, Wolfgang von und Berghaus, Thomas M. (2019): D-Dimer Predicts Disease Severity but Not Long-Term Prognosis in Acute Pulmonary Embolism. In: Clinical and Applied Thrombosis-Hemostasis, Bd. 25

Abstract

D-dimer might be correlated with prognosis in pulmonary embolism (PE). The predictive value of plasma D-dimer for disease severity and survival was investigated in the lowest and highest D-dimer quartile among 200 patients with PE. Patients with high D-dimers were significantly more often hypotensive (P = .001), tachycardic (P = .016), or hypoxemic (P = .001). Pulmonary arterial obstruction index (PAOI) values were significantly higher in the high D-dimer quartile (P < .001). Elevated troponin I (TNI) levels (P < .001), simplified PE severity indices >= 1 (P < .001), right-to-left ventricular (RV/LV) diameter ratios >= 1 (P < .001), and thrombolysis (P = .001) were more frequent in the high D-dimer quartile. D-dimer was associated with RV/LV ratios >= 1 (P = .021), elevated PAOI (P < .001) or TNI levels (P < .001), hypotension (P < .001), tachycardia (P = .003), and hypoxemia (P < .001), but not with long-term all-cause mortality. D-dimer predicts disease severity but not long-term prognosis in acute PE, possibly due to a more aggressive treatment strategy in severely affected patients.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1076-0296
• Sprache: Englisch