Schmid, Christoph; Labopin, Myriam; Schaap, Nicolaas; Veelken, Hendrik; Schleuning, Michael; Stadler, Michael; Finke, Jürgen; Hurst, Erin; Baron, Frederic; Ringden, Olle; Bug, Gesine; Blaise, Didier; Tischer, Johanna; Bloor, Adrian; Esteve, Jordi; Giebel, Sebastian; Savani, Bipin; Gorin, Norbert-Claude; Ciceri, Fabio; Mohty, Mohamad; Nagler, Anton (2019): Prophylactic donor lymphocyte infusion after allogeneic stem cell transplantation in acute leukaemia - a matched pair analysis by the Acute Leukaemia Working Party of EBMT. In: British Journal of Haematology, Vol. 184, No. 5: pp. 782-787 |
Abstract
Strategies for relapse prevention after allogeneic transplantation in acute leukaemia are warranted. A registry-based matched-pair analysis evaluated the efficacy of prophylactic donor lymphocyte infusion (proDLI). Adults receiving proDLI in complete remission (CR) and controls were pair-matched for age, diagnosis, cytogenetics, stage, donor, gender, conditioning and T-cell depletion. Eighty-nine pairs were identified (median follow-up: 6.9 years). Within the entire cohort, no difference was observed. However, among patients with high-risk acute myeloid leukaemia (AML) (unfavourable cytogenetics and/or transplanted beyond first CR), proDLI recipients had improved overall survival (69.8% vs. 40.2% in controls, P = 0.027). ProDLI has moderate efficacy, but can contribute to improved outcome in high-risk AML.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0007-1048 |
Language: | English |
ID Code: | 81460 |
Deposited On: | 15. Dec 2021 14:58 |
Last Modified: | 15. Dec 2021 14:58 |
- BASE
- Schmid, Christoph
- Labopin, Myriam
- Schaap, Nicolaas
- Veelken, Hendrik
- Schleuning, Michael
- Stadler, Michael
- Finke, Jürgen
- Hurst, Erin
- Baron, Frederic
- Ringden, Olle
- Bug, Gesine
- Blaise, Didier
- Tischer, Johanna
- Bloor, Adrian
- Esteve, Jordi
- Giebel, Sebastian
- Savani, Bipin
- Gorin, Norbert-Claude
- Ciceri, Fabio
- Mohty, Mohamad
- Nagler, Anton
- Google Scholar
- Schmid, Christoph
- Labopin, Myriam
- Schaap, Nicolaas
- Veelken, Hendrik
- Schleuning, Michael
- Stadler, Michael
- Finke, Jürgen
- Hurst, Erin
- Baron, Frederic
- Ringden, Olle
- Bug, Gesine
- Blaise, Didier
- Tischer, Johanna
- Bloor, Adrian
- Esteve, Jordi
- Giebel, Sebastian
- Savani, Bipin
- Gorin, Norbert-Claude
- Ciceri, Fabio
- Mohty, Mohamad
- Nagler, Anton