Mavaddat, Nasim; Michailidou, Kyriaki; Dennis, Joe; Lush, Michael; Fachal, Laura; Lee, Andrew; Tyrer, Jonathan P.; Chen, Ting-Huei; Wang, Qin; Bolla, Manjeet K.; Yang, Xin; Adank, Muriel A.; Ahearn, Thomas; Aittomaki, Kristiina; Allen, Jamie; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Arndt, Volker; Aronson, Kristan J.; Auer, Paul L.; Auvinen, Paivi; Barrdahl, Myrto; Freeman, Laura E. Beane; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Bernstein, Leslie; Blomqvist, Carl; Bogdanova, Natalia; Bojesen, Stig E.; Bonanni, Bernardo; Borresen-Dale, Anne-Lise; Brauch, Hiltrud; Bremer, Michael; Brenner, Hermann; Brentnall, Adam; Brock, Ian W.; Brooks-Wilson, Angela; Brucker, Sara Y.; Bruening, Thomas; Burwinkel, Barbara; Campa, Daniele; Carter, Brian D.; Castelao, Jose E.; Chanock, Stephen J.; Chlebowski, Rowan; Christiansen, Hans; Clarke, Christine L.; Collee, J. Margriet; Cordina-Duverger, Emilie; Cornelissen, Sten; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Daly, Mary B.; Devilee, Peter; Doerk, Thilo; dos-Santos-Silva, Isabel; Dumont, Martine; Durcan, Lorraine; Dwek, Miriam; Eccles, Diana M.; Ekici, Arif B.; Eliassen, A. Heather; Ellberg, Carolina; Engel, Christoph; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Figueroa, Jonine; Fletcher, Olivia; Flyger, Henrik; Foersti, Asta; Fritschi, Lin; Gabrielson, Marike; Gago-Dominguez, Manuela; Gapstur, Susan M.; Garcia-Saenz, Jose A.; Gaudet, Mia M.; Georgoulias, Vassilios; Giles, Graham G.; Gilyazova, Irina R.; Glendon, Gord; Goldberg, Mark S.; Goldgar, David E.; Gonzalez-Neira, Anna; Alnaes, Grethe I. Grenaker; Grip, Mervi; Gronwald, Jacek; Grundy, Anne; Guenel, Pascal; Haeberle, Lothar; Hahnen, Eric; Haiman, Christopher A.; Hakansson, Niclas; Hamann, Ute; Hankinson, Susan E.; Harkness, Elaine F.; Hart, Steven N.; He, Wei; Hein, Alexander; Heyworth, Jane; Hillemanns, Peter; Hollestelle, Antoinette; Hooning, Maartje J.; Hoover, Robert N.; Hopper, John L.; Howell, Anthony; Huang, Guanmengqian; Humphreys, Keith; Hunter, David J.; Jakimovska, Milena; Jakubowska, Anna; Janni, Wolfgang; John, Esther M.; Johnson, Nichola; Jones, Michael E.; Jukkola-Vuorinen, Arja; Jung, Audrey; Kaaks, Rudolf; Kaczmarek, Katarzyna; Kataja, Vesa; Keeman, Renske; Kerin, Michael J.; Khusnutdinova, Elza; Kiiski, Johanna; Knight, Julia A.; Ko, Yon-Dschun; Kosma, Veli-Matti; Koutros, Stella; Kristensen, Vessela N.; Krüger, Ute; Kuehl, Tabea; Lambrechts, Diether; Le Marchand, Loic; Lee, Eunjung; Lejbkowicz, Flavio; Lilyquist, Jenna; Lindblom, Annika; Lindstrom, Sara; Lissowska, Jolanta; Lo, Wing-Yee; Loibl, Sibylle; Long, Jirong; Lubinski, Jan; Lux, Michael P.; MacInnis, Robert J.; Maishman, Tom; Makalic, Enes; Kostovska, Ivana Maleva; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Martens, John W. M.; Martinez, Maria Elena; Mavroudis, Dimitrios; McLean, Catriona; Meindl, Alfons; Menon, Usha; Middha, Pooja; Miller, Nicola; Moreno, Fernando; Mulligan, Anna Marie; Mulot, Claire; Munoz-Garzon, Victor M.; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Newman, William G.; Nielsen, Sune F.; Nordestgaard, Borge G.; Norman, Aaron; Offit, Kenneth; Olson, Janet E.; Olsson, Hakan; Orr, Nick; Pankratz, V. Shane; Park-Simon, Tjoung-Won; Perez, Jose I. A.; Perez-Barrios, Clara; Peterlongo, Paolo; Peto, Julian; Pinchev, Mila; Plaseska-Karanfilska, Dijana; Polley, Eric C.; Prentice, Ross; Presneau, Nadege; Prokofyeva, Darya; Purrington, Kristen; Pylkas, Katri; Rack, Brigitte; Radice, Paolo; Rau-Murthy, Rohini; Rennert, Gad; Rennert, Hedy S.; Rhenius, Valerie; Robson, Mark; Romero, Atocha; Ruddy, Kathryn J.; Ruebner, Matthias; Saloustros, Emmanouil; Sandler, Dale P.; Sawyer, Elinor J.; Schmidt, Daniel F.; Schmutzler, Rita K.; Schneeweiss, Andreas; Schoemaker, Minouk J.; Schumacher, Fredrick; Schuermann, Peter; Schwentner, Lukas; Scott, Christopher; Scott, Rodney J.; Seynaeve, Caroline; Shah, Mitul; Sherman, Mark E.; Shrubsole, Martha J.; Shu, Xiao-Ou; Slager, Susan; Smeets, Ann; Sohn, Christof; Soucy, Penny; Southey, Melissa C.; Spinelli, John J.; Stegmaier, Christa; Stone, Jennifer; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Taylor, Jack A.; Terry, Mary Beth; Thoene, Kathrin; Tollenaar, Rob A. E. M.; Tomlinson, Ian; Truong, Therese; Tzardi, Maria; Ulmer, Hans-Ulrich; Untch, Michael; Vachon, Celine M.; van Veen, Elke M.; Vijai, Joseph; Weinberg, Clarice R.; Wendt, Camilla; Whittemore, Alice S.; Wildiers, Hans; Willett, Walter; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R.; Yannoukakos, Drakoulis; Zhang, Yan; Zheng, Wei; Ziogas, Argyrios; Clarke, Christine; Balleine, Rosemary; Baxter, Robert; Braye, Stephen; Carpenter, Jane; Dahlstrom, Jane; Forbes, John; Lee, C. Soon; Marsh, Deborah; Morey, Adrienne; Pathmanathan, Nirmala; Scott, Rodney; Simpson, Peter; Spigelman, Allan; Wilcken, Nicholas; Yip, Desmond; Zeps, Nikolajs; Sexton, Adrienne; Dobrovic, Alex; Christian, Alice; Trainer, Alison; Fellows, Andrew; Shelling, Andrew; De Fazio, Anna; Blackburn, Anneke; Crook, Ashley; Meiser, Bettina; Patterson, Briony; Clarke, Christobel; Saunders, Christobel; Hunt, Clare; Scott, Clare; Amor, David; Ortega, David Gallego; Marsh, Deb; Edkins, Edward; Salisbury, Elizabeth; Haan, Eric; Macrea, Finlay; Farshid, Gelareh; Lindeman, Geoff; Trench, Georgia; Mann, Graham; Giles, Graham; Gill, Grantley; Thorne, Heather; Campbell, Ian; Hickie, Ian; Caldon, Liz; Winship, Ingrid; Cui, James; Flanagan, James; Kollias, James; Visvader, Jane; Taylor, Jessica; Burke, Jo; Saunus, Jodi; Forbs, John; Hopper, John; Beesley, Jonathan; Kirk, Judy; French, Juliet; Tucker, Kathy; Wu, Kathy; Phillips, Kelly; Forrest, Laura; Lipton, Lara; Andrews, Leslie; Lobb, Lizz; Walker, Logan; Kentwell, Maira; Spurdle, Mandy; Cummings, Margaret; Gleeson, Margaret; Harris, Marion; Jenkins, Mark; Young, Mary Anne; Delatycki, Martin; Wallis, Mathew; Burgess, Matthew; Brown, Melissa; Southey, Melissa; Bogwitz, Michael; Field, Michael; Friedlander, Michael; Gattas, Michael; Saleh, Mona; Aghmesheh, Morteza; Hayward, Nick; Pachter, Nick; Cohen, Paul; Duijf, Pascal; James, Paul; Simpson, Pete; Fong, Peter; Butow, Phyllis; Williams, Rachael; Kefford, Rick; Simard, Jacques; Balleine, Rose-Mary; Dawson, Sarah-Jane; Lok, Sheau; O'Connell, Shona; Greening, Sian; Nightingale, Sophie; Edwards, Stacey; Fox, Stephen; McLachlan, Sue-Anne; Lakhani, Sunil; Dudding, Tracy; Antill, Yoland; Sahlberg, Kristine K.; Ottestad, Lars; Karesen, Rolf; Schlichting, Ellen; Holmen, Marit Muri; Sauer, Toril; Haakensen, Vilde; Engebraten, Olav; Naume, Bjorn; Fossa, Alexander; Kiserud, Cecile E.; Reinertsen, Kristin; Helland, Aslaug; Riis, Margit; Geisler, Jürgen; Dunning, Alison M.; Thompson, Deborah J.; Chenevix-Trench, Georgia; Chang-Claude, Jenny; Schmidt, Marjanka K.; Hall, Per; Milne, Roger L.; Pharoah, Paul D. P.; Antoniou, Antonis C.; Chatterjee, Nilanjan; Kraft, Peter; Garcia-Closas, Montserrat; Easton, Douglas F. (2019): Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. In: American Journal of Human Genetics, Vol. 104, No. 1: pp. 21-34 |
Abstract
Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.
Item Type: | Journal article |
---|---|
Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0002-9297 |
Language: | English |
ID Code: | 81465 |
Deposited On: | 15. Dec 2021 14:58 |
Last Modified: | 17. Mar 2022 16:03 |
- BASE
- Mavaddat, Nasim
- Michailidou, Kyriaki
- Dennis, Joe
- Lush, Michael
- Fachal, Laura
- Lee, Andrew
- Tyrer, Jonathan P.
- Chen, Ting-Huei
- Wang, Qin
- Bolla, Manjeet K.
- Yang, Xin
- Adank, Muriel A.
- Ahearn, Thomas
- Aittomaki, Kristiina
- Allen, Jamie
- Andrulis, Irene L.
- Anton-Culver, Hoda
- Antonenkova, Natalia N.
- Arndt, Volker
- Aronson, Kristan J.
- Auer, Paul L.
- Auvinen, Paivi
- Barrdahl, Myrto
- Freeman, Laura E. Beane
- Beckmann, Matthias W.
- Behrens, Sabine
- Benitez, Javier
- Bermisheva, Marina
- Bernstein, Leslie
- Blomqvist, Carl
- Bogdanova, Natalia
- Bojesen, Stig E.
- Bonanni, Bernardo
- Borresen-Dale, Anne-Lise
- Brauch, Hiltrud
- Bremer, Michael
- Brenner, Hermann
- Brentnall, Adam
- Brock, Ian W.
- Brooks-Wilson, Angela
- Brucker, Sara Y.
- Bruening, Thomas
- Burwinkel, Barbara
- Campa, Daniele
- Carter, Brian D.
- Castelao, Jose E.
- Chanock, Stephen J.
- Chlebowski, Rowan
- Christiansen, Hans
- Clarke, Christine L.
- Collee, J. Margriet
- Cordina-Duverger, Emilie
- Cornelissen, Sten
- Couch, Fergus J.
- Cox, Angela
- Cross, Simon S.
- Czene, Kamila
- Daly, Mary B.
- Devilee, Peter
- Doerk, Thilo
- dos-Santos-Silva, Isabel
- Dumont, Martine
- Durcan, Lorraine
- Dwek, Miriam
- Eccles, Diana M.
- Ekici, Arif B.
- Eliassen, A. Heather
- Ellberg, Carolina
- Engel, Christoph
- Eriksson, Mikael
- Evans, D. Gareth
- Fasching, Peter A.
- Figueroa, Jonine
- Fletcher, Olivia
- Flyger, Henrik
- Foersti, Asta
- Fritschi, Lin
- Gabrielson, Marike
- Gago-Dominguez, Manuela
- Gapstur, Susan M.
- Garcia-Saenz, Jose A.
- Gaudet, Mia M.
- Georgoulias, Vassilios
- Giles, Graham G.
- Gilyazova, Irina R.
- Glendon, Gord
- Goldberg, Mark S.
- Goldgar, David E.
- Gonzalez-Neira, Anna
- Alnaes, Grethe I. Grenaker
- Grip, Mervi
- Gronwald, Jacek
- Grundy, Anne
- Guenel, Pascal
- Haeberle, Lothar
- Hahnen, Eric
- Haiman, Christopher A.
- Hakansson, Niclas
- Hamann, Ute
- Hankinson, Susan E.
- Harkness, Elaine F.
- Hart, Steven N.
- He, Wei
- Hein, Alexander
- Heyworth, Jane
- Hillemanns, Peter
- Hollestelle, Antoinette
- Hooning, Maartje J.
- Hoover, Robert N.
- Hopper, John L.
- Howell, Anthony
- Huang, Guanmengqian
- Humphreys, Keith
- Hunter, David J.
- Jakimovska, Milena
- Jakubowska, Anna
- Janni, Wolfgang
- John, Esther M.
- Johnson, Nichola
- Jones, Michael E.
- Jukkola-Vuorinen, Arja
- Jung, Audrey
- Kaaks, Rudolf
- Kaczmarek, Katarzyna
- Kataja, Vesa
- Keeman, Renske
- Kerin, Michael J.
- Khusnutdinova, Elza
- Kiiski, Johanna
- Knight, Julia A.
- Ko, Yon-Dschun
- Kosma, Veli-Matti
- Koutros, Stella
- Kristensen, Vessela N.
- Krüger, Ute
- Kuehl, Tabea
- Lambrechts, Diether
- Le Marchand, Loic
- Lee, Eunjung
- Lejbkowicz, Flavio
- Lilyquist, Jenna
- Lindblom, Annika
- Lindstrom, Sara
- Lissowska, Jolanta
- Lo, Wing-Yee
- Loibl, Sibylle
- Long, Jirong
- Lubinski, Jan
- Lux, Michael P.
- MacInnis, Robert J.
- Maishman, Tom
- Makalic, Enes
- Kostovska, Ivana Maleva
- Mannermaa, Arto
- Manoukian, Siranoush
- Margolin, Sara
- Martens, John W. M.
- Martinez, Maria Elena
- Mavroudis, Dimitrios
- McLean, Catriona
- Meindl, Alfons
- Menon, Usha
- Middha, Pooja
- Miller, Nicola
- Moreno, Fernando
- Mulligan, Anna Marie
- Mulot, Claire
- Munoz-Garzon, Victor M.
- Neuhausen, Susan L.
- Nevanlinna, Heli
- Neven, Patrick
- Newman, William G.
- Nielsen, Sune F.
- Nordestgaard, Borge G.
- Norman, Aaron
- Offit, Kenneth
- Olson, Janet E.
- Olsson, Hakan
- Orr, Nick
- Pankratz, V. Shane
- Park-Simon, Tjoung-Won
- Perez, Jose I. A.
- Perez-Barrios, Clara
- Peterlongo, Paolo
- Peto, Julian
- Pinchev, Mila
- Plaseska-Karanfilska, Dijana
- Polley, Eric C.
- Prentice, Ross
- Presneau, Nadege
- Prokofyeva, Darya
- Purrington, Kristen
- Pylkas, Katri
- Rack, Brigitte
- Radice, Paolo
- Rau-Murthy, Rohini
- Rennert, Gad
- Rennert, Hedy S.
- Rhenius, Valerie
- Robson, Mark
- Romero, Atocha
- Ruddy, Kathryn J.
- Ruebner, Matthias
- Saloustros, Emmanouil
- Sandler, Dale P.
- Sawyer, Elinor J.
- Schmidt, Daniel F.
- Schmutzler, Rita K.
- Schneeweiss, Andreas
- Schoemaker, Minouk J.
- Schumacher, Fredrick
- Schuermann, Peter
- Schwentner, Lukas
- Scott, Christopher
- Scott, Rodney J.
- Seynaeve, Caroline
- Shah, Mitul
- Sherman, Mark E.
- Shrubsole, Martha J.
- Shu, Xiao-Ou
- Slager, Susan
- Smeets, Ann
- Sohn, Christof
- Soucy, Penny
- Southey, Melissa C.
- Spinelli, John J.
- Stegmaier, Christa
- Stone, Jennifer
- Swerdlow, Anthony J.
- Tamimi, Rulla M.
- Tapper, William J.
- Taylor, Jack A.
- Terry, Mary Beth
- Thoene, Kathrin
- Tollenaar, Rob A. E. M.
- Tomlinson, Ian
- Truong, Therese
- Tzardi, Maria
- Ulmer, Hans-Ulrich
- Untch, Michael
- Vachon, Celine M.
- van Veen, Elke M.
- Vijai, Joseph
- Weinberg, Clarice R.
- Wendt, Camilla
- Whittemore, Alice S.
- Wildiers, Hans
- Willett, Walter
- Winqvist, Robert
- Wolk, Alicja
- Yang, Xiaohong R.
- Yannoukakos, Drakoulis
- Zhang, Yan
- Zheng, Wei
- Ziogas, Argyrios
- Clarke, Christine
- Balleine, Rosemary
- Baxter, Robert
- Braye, Stephen
- Carpenter, Jane
- Dahlstrom, Jane
- Forbes, John
- Lee, C. Soon
- Marsh, Deborah
- Morey, Adrienne
- Pathmanathan, Nirmala
- Scott, Rodney
- Simpson, Peter
- Spigelman, Allan
- Wilcken, Nicholas
- Yip, Desmond
- Zeps, Nikolajs
- Sexton, Adrienne
- Dobrovic, Alex
- Christian, Alice
- Trainer, Alison
- Fellows, Andrew
- Shelling, Andrew
- De Fazio, Anna
- Blackburn, Anneke
- Crook, Ashley
- Meiser, Bettina
- Patterson, Briony
- Clarke, Christobel
- Saunders, Christobel
- Hunt, Clare
- Scott, Clare
- Amor, David
- Ortega, David Gallego
- Marsh, Deb
- Edkins, Edward
- Salisbury, Elizabeth
- Haan, Eric
- Macrea, Finlay
- Farshid, Gelareh
- Lindeman, Geoff
- Trench, Georgia
- Mann, Graham
- Giles, Graham
- Gill, Grantley
- Thorne, Heather
- Campbell, Ian
- Hickie, Ian
- Caldon, Liz
- Winship, Ingrid
- Cui, James
- Flanagan, James
- Kollias, James
- Visvader, Jane
- Taylor, Jessica
- Burke, Jo
- Saunus, Jodi
- Forbs, John
- Hopper, John
- Beesley, Jonathan
- Kirk, Judy
- French, Juliet
- Tucker, Kathy
- Wu, Kathy
- Phillips, Kelly
- Forrest, Laura
- Lipton, Lara
- Andrews, Leslie
- Lobb, Lizz
- Walker, Logan
- Kentwell, Maira
- Spurdle, Mandy
- Cummings, Margaret
- Gleeson, Margaret
- Harris, Marion
- Jenkins, Mark
- Young, Mary Anne
- Delatycki, Martin
- Wallis, Mathew
- Burgess, Matthew
- Brown, Melissa
- Southey, Melissa
- Bogwitz, Michael
- Field, Michael
- Friedlander, Michael
- Gattas, Michael
- Saleh, Mona
- Aghmesheh, Morteza
- Hayward, Nick
- Pachter, Nick
- Cohen, Paul
- Duijf, Pascal
- James, Paul
- Simpson, Pete
- Fong, Peter
- Butow, Phyllis
- Williams, Rachael
- Kefford, Rick
- Simard, Jacques
- Balleine, Rose-Mary
- Dawson, Sarah-Jane
- Lok, Sheau
- O'Connell, Shona
- Greening, Sian
- Nightingale, Sophie
- Edwards, Stacey
- Fox, Stephen
- McLachlan, Sue-Anne
- Lakhani, Sunil
- Dudding, Tracy
- Antill, Yoland
- Sahlberg, Kristine K.
- Ottestad, Lars
- Karesen, Rolf
- Schlichting, Ellen
- Holmen, Marit Muri
- Sauer, Toril
- Haakensen, Vilde
- Engebraten, Olav
- Naume, Bjorn
- Fossa, Alexander
- Kiserud, Cecile E.
- Reinertsen, Kristin
- Helland, Aslaug
- Riis, Margit
- Geisler, Jürgen
- Dunning, Alison M.
- Thompson, Deborah J.
- Chenevix-Trench, Georgia
- Chang-Claude, Jenny
- Schmidt, Marjanka K.
- Hall, Per
- Milne, Roger L.
- Pharoah, Paul D. P.
- Antoniou, Antonis C.
- Chatterjee, Nilanjan
- Kraft, Peter
- Garcia-Closas, Montserrat
- Easton, Douglas F.
- Google Scholar
- Mavaddat, Nasim
- Michailidou, Kyriaki
- Dennis, Joe
- Lush, Michael
- Fachal, Laura
- Lee, Andrew
- Tyrer, Jonathan P.
- Chen, Ting-Huei
- Wang, Qin
- Bolla, Manjeet K.
- Yang, Xin
- Adank, Muriel A.
- Ahearn, Thomas
- Aittomaki, Kristiina
- Allen, Jamie
- Andrulis, Irene L.
- Anton-Culver, Hoda
- Antonenkova, Natalia N.
- Arndt, Volker
- Aronson, Kristan J.
- Auer, Paul L.
- Auvinen, Paivi
- Barrdahl, Myrto
- Freeman, Laura E. Beane
- Beckmann, Matthias W.
- Behrens, Sabine
- Benitez, Javier
- Bermisheva, Marina
- Bernstein, Leslie
- Blomqvist, Carl
- Bogdanova, Natalia
- Bojesen, Stig E.
- Bonanni, Bernardo
- Borresen-Dale, Anne-Lise
- Brauch, Hiltrud
- Bremer, Michael
- Brenner, Hermann
- Brentnall, Adam
- Brock, Ian W.
- Brooks-Wilson, Angela
- Brucker, Sara Y.
- Bruening, Thomas
- Burwinkel, Barbara
- Campa, Daniele
- Carter, Brian D.
- Castelao, Jose E.
- Chanock, Stephen J.
- Chlebowski, Rowan
- Christiansen, Hans
- Clarke, Christine L.
- Collee, J. Margriet
- Cordina-Duverger, Emilie
- Cornelissen, Sten
- Couch, Fergus J.
- Cox, Angela
- Cross, Simon S.
- Czene, Kamila
- Daly, Mary B.
- Devilee, Peter
- Doerk, Thilo
- dos-Santos-Silva, Isabel
- Dumont, Martine
- Durcan, Lorraine
- Dwek, Miriam
- Eccles, Diana M.
- Ekici, Arif B.
- Eliassen, A. Heather
- Ellberg, Carolina
- Engel, Christoph
- Eriksson, Mikael
- Evans, D. Gareth
- Fasching, Peter A.
- Figueroa, Jonine
- Fletcher, Olivia
- Flyger, Henrik
- Foersti, Asta
- Fritschi, Lin
- Gabrielson, Marike
- Gago-Dominguez, Manuela
- Gapstur, Susan M.
- Garcia-Saenz, Jose A.
- Gaudet, Mia M.
- Georgoulias, Vassilios
- Giles, Graham G.
- Gilyazova, Irina R.
- Glendon, Gord
- Goldberg, Mark S.
- Goldgar, David E.
- Gonzalez-Neira, Anna
- Alnaes, Grethe I. Grenaker
- Grip, Mervi
- Gronwald, Jacek
- Grundy, Anne
- Guenel, Pascal
- Haeberle, Lothar
- Hahnen, Eric
- Haiman, Christopher A.
- Hakansson, Niclas
- Hamann, Ute
- Hankinson, Susan E.
- Harkness, Elaine F.
- Hart, Steven N.
- He, Wei
- Hein, Alexander
- Heyworth, Jane
- Hillemanns, Peter
- Hollestelle, Antoinette
- Hooning, Maartje J.
- Hoover, Robert N.
- Hopper, John L.
- Howell, Anthony
- Huang, Guanmengqian
- Humphreys, Keith
- Hunter, David J.
- Jakimovska, Milena
- Jakubowska, Anna
- Janni, Wolfgang
- John, Esther M.
- Johnson, Nichola
- Jones, Michael E.
- Jukkola-Vuorinen, Arja
- Jung, Audrey
- Kaaks, Rudolf
- Kaczmarek, Katarzyna
- Kataja, Vesa
- Keeman, Renske
- Kerin, Michael J.
- Khusnutdinova, Elza
- Kiiski, Johanna
- Knight, Julia A.
- Ko, Yon-Dschun
- Kosma, Veli-Matti
- Koutros, Stella
- Kristensen, Vessela N.
- Krüger, Ute
- Kuehl, Tabea
- Lambrechts, Diether
- Le Marchand, Loic
- Lee, Eunjung
- Lejbkowicz, Flavio
- Lilyquist, Jenna
- Lindblom, Annika
- Lindstrom, Sara
- Lissowska, Jolanta
- Lo, Wing-Yee
- Loibl, Sibylle
- Long, Jirong
- Lubinski, Jan
- Lux, Michael P.
- MacInnis, Robert J.
- Maishman, Tom
- Makalic, Enes
- Kostovska, Ivana Maleva
- Mannermaa, Arto
- Manoukian, Siranoush
- Margolin, Sara
- Martens, John W. M.
- Martinez, Maria Elena
- Mavroudis, Dimitrios
- McLean, Catriona
- Meindl, Alfons
- Menon, Usha
- Middha, Pooja
- Miller, Nicola
- Moreno, Fernando
- Mulligan, Anna Marie
- Mulot, Claire
- Munoz-Garzon, Victor M.
- Neuhausen, Susan L.
- Nevanlinna, Heli
- Neven, Patrick
- Newman, William G.
- Nielsen, Sune F.
- Nordestgaard, Borge G.
- Norman, Aaron
- Offit, Kenneth
- Olson, Janet E.
- Olsson, Hakan
- Orr, Nick
- Pankratz, V. Shane
- Park-Simon, Tjoung-Won
- Perez, Jose I. A.
- Perez-Barrios, Clara
- Peterlongo, Paolo
- Peto, Julian
- Pinchev, Mila
- Plaseska-Karanfilska, Dijana
- Polley, Eric C.
- Prentice, Ross
- Presneau, Nadege
- Prokofyeva, Darya
- Purrington, Kristen
- Pylkas, Katri
- Rack, Brigitte
- Radice, Paolo
- Rau-Murthy, Rohini
- Rennert, Gad
- Rennert, Hedy S.
- Rhenius, Valerie
- Robson, Mark
- Romero, Atocha
- Ruddy, Kathryn J.
- Ruebner, Matthias
- Saloustros, Emmanouil
- Sandler, Dale P.
- Sawyer, Elinor J.
- Schmidt, Daniel F.
- Schmutzler, Rita K.
- Schneeweiss, Andreas
- Schoemaker, Minouk J.
- Schumacher, Fredrick
- Schuermann, Peter
- Schwentner, Lukas
- Scott, Christopher
- Scott, Rodney J.
- Seynaeve, Caroline
- Shah, Mitul
- Sherman, Mark E.
- Shrubsole, Martha J.
- Shu, Xiao-Ou
- Slager, Susan
- Smeets, Ann
- Sohn, Christof
- Soucy, Penny
- Southey, Melissa C.
- Spinelli, John J.
- Stegmaier, Christa
- Stone, Jennifer
- Swerdlow, Anthony J.
- Tamimi, Rulla M.
- Tapper, William J.
- Taylor, Jack A.
- Terry, Mary Beth
- Thoene, Kathrin
- Tollenaar, Rob A. E. M.
- Tomlinson, Ian
- Truong, Therese
- Tzardi, Maria
- Ulmer, Hans-Ulrich
- Untch, Michael
- Vachon, Celine M.
- van Veen, Elke M.
- Vijai, Joseph
- Weinberg, Clarice R.
- Wendt, Camilla
- Whittemore, Alice S.
- Wildiers, Hans
- Willett, Walter
- Winqvist, Robert
- Wolk, Alicja
- Yang, Xiaohong R.
- Yannoukakos, Drakoulis
- Zhang, Yan
- Zheng, Wei
- Ziogas, Argyrios
- Clarke, Christine
- Balleine, Rosemary
- Baxter, Robert
- Braye, Stephen
- Carpenter, Jane
- Dahlstrom, Jane
- Forbes, John
- Lee, C. Soon
- Marsh, Deborah
- Morey, Adrienne
- Pathmanathan, Nirmala
- Scott, Rodney
- Simpson, Peter
- Spigelman, Allan
- Wilcken, Nicholas
- Yip, Desmond
- Zeps, Nikolajs
- Sexton, Adrienne
- Dobrovic, Alex
- Christian, Alice
- Trainer, Alison
- Fellows, Andrew
- Shelling, Andrew
- De Fazio, Anna
- Blackburn, Anneke
- Crook, Ashley
- Meiser, Bettina
- Patterson, Briony
- Clarke, Christobel
- Saunders, Christobel
- Hunt, Clare
- Scott, Clare
- Amor, David
- Ortega, David Gallego
- Marsh, Deb
- Edkins, Edward
- Salisbury, Elizabeth
- Haan, Eric
- Macrea, Finlay
- Farshid, Gelareh
- Lindeman, Geoff
- Trench, Georgia
- Mann, Graham
- Giles, Graham
- Gill, Grantley
- Thorne, Heather
- Campbell, Ian
- Hickie, Ian
- Caldon, Liz
- Winship, Ingrid
- Cui, James
- Flanagan, James
- Kollias, James
- Visvader, Jane
- Taylor, Jessica
- Burke, Jo
- Saunus, Jodi
- Forbs, John
- Hopper, John
- Beesley, Jonathan
- Kirk, Judy
- French, Juliet
- Tucker, Kathy
- Wu, Kathy
- Phillips, Kelly
- Forrest, Laura
- Lipton, Lara
- Andrews, Leslie
- Lobb, Lizz
- Walker, Logan
- Kentwell, Maira
- Spurdle, Mandy
- Cummings, Margaret
- Gleeson, Margaret
- Harris, Marion
- Jenkins, Mark
- Young, Mary Anne
- Delatycki, Martin
- Wallis, Mathew
- Burgess, Matthew
- Brown, Melissa
- Southey, Melissa
- Bogwitz, Michael
- Field, Michael
- Friedlander, Michael
- Gattas, Michael
- Saleh, Mona
- Aghmesheh, Morteza
- Hayward, Nick
- Pachter, Nick
- Cohen, Paul
- Duijf, Pascal
- James, Paul
- Simpson, Pete
- Fong, Peter
- Butow, Phyllis
- Williams, Rachael
- Kefford, Rick
- Simard, Jacques
- Balleine, Rose-Mary
- Dawson, Sarah-Jane
- Lok, Sheau
- O'Connell, Shona
- Greening, Sian
- Nightingale, Sophie
- Edwards, Stacey
- Fox, Stephen
- McLachlan, Sue-Anne
- Lakhani, Sunil
- Dudding, Tracy
- Antill, Yoland
- Sahlberg, Kristine K.
- Ottestad, Lars
- Karesen, Rolf
- Schlichting, Ellen
- Holmen, Marit Muri
- Sauer, Toril
- Haakensen, Vilde
- Engebraten, Olav
- Naume, Bjorn
- Fossa, Alexander
- Kiserud, Cecile E.
- Reinertsen, Kristin
- Helland, Aslaug
- Riis, Margit
- Geisler, Jürgen
- Dunning, Alison M.
- Thompson, Deborah J.
- Chenevix-Trench, Georgia
- Chang-Claude, Jenny
- Schmidt, Marjanka K.
- Hall, Per
- Milne, Roger L.
- Pharoah, Paul D. P.
- Antoniou, Antonis C.
- Chatterjee, Nilanjan
- Kraft, Peter
- Garcia-Closas, Montserrat
- Easton, Douglas F.