Logo Logo
Switch Language to German

Mahoney, John M.; Mills, James D.; Muhlebner, Angelika; Noebels, Jeffrey; Potschka, Heidrun; Simonato, Michele and Kobow, Katja (2019): 2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches. In: Epilepsia, Vol. 60, No. 6: pp. 1045-1053

Full text not available from 'Open Access LMU'.


The revolution in high-throughput omics technologies has dramatically expanded our understanding of the epilepsies as complex diseases. It is now clear that further progress in treating the full spectrum of seizure disorders requires a systems-level framework for analyzing and integrating data from multiple omics technologies that moves beyond the search for single molecular alterations to an understanding of dysregulated pathways in epilepsy. Taking such a pathway-centered view requires further integrating the tools of systems biology into epilepsy research. In this appraisal, we highlight and summarize systems biology approaches in basic epilepsy studies as they were discussed during the 2017 Workshop on the Neurobiology of Epilepsy (WONOEP). During the 3-day event, participants exchanged emerging results and thoughts on developing the systems biology of epilepsy, and the promise and limitations of these approaches for the near term.

Actions (login required)

View Item View Item