Epidemiological characteristics, clinical manifestations, and treatment outcome of 139 paediatric Ebola patients treated at a Sierra Leone Ebola treatment center

Kangbai, Jia Bainga; Heumann, Christian; Hoelscher, Michael; Sahr, Foday und Froeschl, Guenter (2019): Epidemiological characteristics, clinical manifestations, and treatment outcome of 139 paediatric Ebola patients treated at a Sierra Leone Ebola treatment center. In: BMC Infectious Diseases, Bd. 19, 81

Abstract

BackgroundThe West Africa Ebola Virus Disease (EVD) outbreak in 2014-2016 was declared by the World Health Organization (WHO) a public health emergency of international concern. Most of the previous studies done in Sierra Leone relating to the clinical and epidemiological features of EVD during the 2014-2016 West African outbreak focused on adult EVD patients. There have been conflicting reports about the effects of EVD on children during previous outbreaks.MethodsThis is an observational retrospective analysis of medical data of all laboratory confirmed paediatric EVD patients below 15years of age who were admitted at the 34 Military Hospital Ebola Treatment Center (ETC) in Wilberforce, Sierra Leone between June 2014 to April 2015. We analyzed the sociodemographic and clinical characteristics of paediatric EVD cases contained in case report forms that were collected by Ebola surveillance officers and clinicians at the 34 Military Hospital ETC. Both univariate and multivariate logistic regression models were used to determine the sociodemographic and clinical characteristics of paediatric EVD patients that were associated with EVD facility-based mortality.ResultsThe majority of the paediatric EVD cases in this study were female (56.1%), pupils (51.1%), and 43.2% belonged to the age group between 10years and below 15years. The median age of the paediatric EVD cases was 9years (interquartile range=4 to 11years). Adjusting for other covariates in the model, male paediatric EVD patient (AOR=13.4, 95% CI=[2.07-156-18], p<0.05), EVD patient with abdominal pain (AOR=11.0, 95% CI=[1.30-161.81], p<0.05), vomiting (AOR=35.7, 95% CI=[3.43-833.73], p<0.05), signs of conjunctivitis (AOR=17.4, 95% CI=[1.53-342.21], p<0.05) and difficulty in breathing (AOR=23.3, 95% CI=[1.92-713.01], p<0.05) at the time of admission had increased odds of dying during EVD treatment.ConclusionsWe recommend the adoption of case definitions currently in vigour to cater for specific characteristics of paediatric patients. Subgroups that can be identified by applying the model developed in this study may require special attention and intensified care.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Mathematik, Informatik und Statistik > Statistik ; Medizin
• Themengebiete: 500 Naturwissenschaften und Mathematik > 510 Mathematik ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Sprache: Englisch