Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings

Buchegger, Sascha; Kamenac, Andrej; Fuchs, Sven; Herrmann, Rudolf; Houdek, Pia; Gorzelanny, Christian; Obermeier, Andreas; Heller, Stephan; Burgkart, Rainer; Stritzker, Bernd; Wixforth, Achim und Westerhausen, Christoph (2019): Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings. In: Scientific Reports, Bd. 9, 17246

Abstract

One of the main challenges in endoprosthesis surgeries are implant-associated infections and aseptic-loosenings, caused by wear debris. To combat these problems, the requirements to surfaces of endoprostheses are wear-resistance, low cytotoxicity and antimicrobial efficacy. We here present antimicrobial coatings with a smart, adaptive release of metal ions in case of infection, based on ZnO-nanoparticles embedded in diamond-like carbon (DLC). The Zn2+ ion release of these coatings in aqueous environments reacts and adapts smartly on inflammations accompanied by acidosis. Moreover, we show that this increased ion release comes along with an increased toxicity to fibroblastic cells (L929) and bacteria (Staphylococcus aureus subsp. aureus, resistant to methicillin and oxacillin. (ATCC 43300, MRSA) and Staphylococcus epidermidis (ATCC 35984, S. epidermidis). Interestingly, the antimicrobial effect and the cytotoxicity of the coatings increase with a reduction of the pH value from 7.4 to 6.4, but not further to pH 5.4.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Physik
• Fakultätsübergreifende Einrichtungen: Center for NanoScience (CENS)
• Themengebiete: 500 Naturwissenschaften und Mathematik > 530 Physik ; 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften
• ISSN: 2045-2322
• Sprache: Englisch