Ru(TAP)(3)(2+) uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

Vanderlinden, Willem; Kolbeck, Pauline J.; Frederickx, Wout; Konrad, Sebastian F.; Nicolaus, Thomas; Lampe, Carola; Urban, Alexander S.; Moucheron, Cecile und Lipfert, Jan (2019): Ru(TAP)(3)(2+) uses multivalent binding to accelerate and constrain photo-adduct formation on DNA. In: Chemical Communications, Vol. 55, No. 60: pp. 8764-8767

Abstract

Ru(II)-complexes with polyazaaromatic ligands can undergo direct electron transfer with guanine nucleobases on blue light excitation that results in DNA lesions with phototherapeutic potential. Here we use single molecule approaches to demonstrate DNA binding mode heterogeneity and evaluate how multivalent binding governs the photochemistry of [ Ru(TAP)(3)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene).

• Item Type: Journal article
• Faculties: Physics
• Subjects: 500 Science > 530 Physics
• ISSN: 1359-7345
• Language: English