Abstract
The thiolation of pyridine-2-sulfonamides using magnesium thiolates is reported. The ortho -functionalizations of these sulfonamides using TMPMgCl center dot LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by electrophilic quenching produced a range of 3-functionalized pyridine-2-sulfonamides, which were subsequently converted into the corresponding thioethers. Finally, symmetric or asymmetric diorganodisulfides were employed as electrophiles in a one-pot ortho -functionalization-thiolation procedure, leading to pyridine 2,3-disubstituted dithioethers.
| Item Type: | Journal article |
|---|---|
| Faculties: | Chemistry and Pharmacy > Department of Chemistry |
| Subjects: | 500 Science > 540 Chemistry |
| ISSN: | 0039-7881 |
| Language: | English |
| Item ID: | 83280 |
| Date Deposited: | 15. Dec 2021 15:07 |
| Last Modified: | 15. Dec 2021 15:07 |
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