Cobalt-Catalyzed Cross-Couplings and Electrophilic Aminations using Organozinc Pivalates

Lutter, Ferdinand H.; Grassl, Simon; Grokenberger, Lucie; Hofmayer, Maximilian S.; Chen, Yi-Hung und Knochel, Paul (2019): Cobalt-Catalyzed Cross-Couplings and Electrophilic Aminations using Organozinc Pivalates. In: Chemcatchem, Vol. 11, No. 21: pp. 5188-5197

Abstract

Transition metal catalyzed cross-couplings are essential methods in organic synthesis. Due to their comparable low toxicity and price, cobalt-salts offer a useful alternative to other common metal-catalysts (e.g. palladium-complexes). In this review, we report that cobalt-catalysts are especially well suited for cross-coupling reactions with organozinc pivalates, a class of organozinc reagents with enhanced stability towards air and moisture. Furthermore, we discuss applications of cobalt-catalysis in Negishi cross-coupling reactions (sp(2)-sp(2), sp-sp(2), sp-sp(3)) as well as electrophilic aminations using organozinc reagents.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1867-3880
• Language: English