Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives

Lutter, Ferdinand H.; Grokenberger, Lucie; Hofmayer, Maximilian S. und Knochel, Paul (2019): Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives. In: Chemical Science, Vol. 10, No. 35: pp. 8241-8245

Abstract

A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S-pyridyl thioesters with (hetero)arylzinc pivalates is reported. The thioesters were prepared directly from the corresponding carboxylic acids under mild conditions, thus tolerating sensitive functional groups. Acylations of alpha-chiral S-pyridyl esters proceeded with very high stereoretention leading to optically enriched alpha-chiral ketones.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 2041-6520
• Language: English