Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives

Lutter, Ferdinand H.; Grokenberger, Lucie; Hofmayer, Maximilian S. und Knochel, Paul (2019): Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives. In: Chemical Science, Bd. 10, Nr. 35: S. 8241-8245

Abstract

A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S-pyridyl thioesters with (hetero)arylzinc pivalates is reported. The thioesters were prepared directly from the corresponding carboxylic acids under mild conditions, thus tolerating sensitive functional groups. Acylations of alpha-chiral S-pyridyl esters proceeded with very high stereoretention leading to optically enriched alpha-chiral ketones.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 2041-6520
• Sprache: Englisch