Amination of 2-Pyridinesulfonic and 8-Quinolinesulfonic Acids with Magnesium Amides

Balkenhohl, Moritz; Valsamidou, Vasiliki and Knochel, Paul (2019): Amination of 2-Pyridinesulfonic and 8-Quinolinesulfonic Acids with Magnesium Amides. In: European Journal of Organic Chemistry, Vol. 2019, No. 31-32: pp. 5165-5168

Abstract

The amination of 2-pyridine- and 8-quinolinesulfonic acids using magnesium amides of the type R2NMgCl center dot LiCl is reported. Thus, several cyclic and acyclic amines were converted into the corresponding amides using iPrMgCl center dot LiCl, which reacted readily with sulfonic acids to produce aminopyridines and aminoquinolines. Various amines which are attractive in drug chemistry were suitable for this transformation.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1434-193X
• Language: English