Exact distance measurements for structure and dynamics in solid proteins by fast-magic-anglespinning NMR

Grohe, Kristof; Nimerovsky, Evgeny; Singh, Himanshu; Vasa, Suresh K.; Soeldner, Benedikt; Vogeli, Beat; Rienstra, Chad M. und Linser, Rasmus (2019): Exact distance measurements for structure and dynamics in solid proteins by fast-magic-anglespinning NMR. In: Chemical Communications, Vol. 55, No. 55: pp. 7899-7902

Abstract

Fast-magic-angle-spinning solid-state NMR is a developing technique for determination of protein structure and dynamics. Proton-proton correlations usually lead to rough distance restraints, a serious hurdle towards high-resolution structures. Analogous to the `` eNOE" concept in solution, an integrative approach for more accurate restraints enables improved structural accuracy with minimal analytical effort.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 1359-7345
• Language: English