Lewis Acid Directed Regioselective Metalations of Pyridazine

Balkenhohl, Moritz; Jangra, Harish; Lenz, Tobias; Ebeling, Marian; Zipse, Hendrik; Karaghiosoff, Konstantin und Knochel, Paul (2019): Lewis Acid Directed Regioselective Metalations of Pyridazine. In: Angewandte Chemie-International Edition, Bd. 58, Nr. 27: S. 9244-9247

Abstract

Mono- or bidentate boron Lewis acids trigger a regioselective magnesiation or zincation of pyridazine in position C3 (ortho product) or C4 meta product). The regioselectivity of the metalation was rationalized with the help of calculated pK(a) values of both pyridazine and pyridazine/Lewis acid complexes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1433-7851
• Sprache: Englisch