Synthesis and biological evaluation of (+/-)-hippolachnin and analogs

Winter, Nils; Rupcic, Zeljka; Stadler, Marc und Trauner, Dirk (2019): Synthesis and biological evaluation of (+/-)-hippolachnin and analogs. In: Journal of Antibiotics, Bd. 72, Nr. 6: S. 375-383

Abstract

Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0021-8820
• Sprache: Englisch