Synthesis and biological evaluation of (+/-)-hippolachnin and analogs

Winter, Nils; Rupcic, Zeljka; Stadler, Marc und Trauner, Dirk (2019): Synthesis and biological evaluation of (+/-)-hippolachnin and analogs. In: Journal of Antibiotics, Vol. 72, No. 6: pp. 375-383

Abstract

Due its unique structure and its reported potent antifungal activity, the marine polyketide hippolachnin A (1) has attracted much attention in the synthetic community. Herein, we describe the development of a concise, diversifiable and scalable synthesis of the racemic natural product, which serves as a platform for the generation of bioactive analogues. Biological testing of our synthetic material did not confirm the reported antifungal activity of hippolachnin A but unraveled moderate activity against nematodes and microbes.

• Item Type: Journal article
• Faculties: Chemistry and Pharmacy > Department of Chemistry
• Subjects: 500 Science > 540 Chemistry
• ISSN: 0021-8820
• Language: English