Concise Asymmetric Synthesis of Kweichowenol A

Konrad, David B.; Kicin, Bilal und Trauner, Dirk (2019): Concise Asymmetric Synthesis of Kweichowenol A. In: Synlett, Bd. 30, Nr. 4: S. 383-386

Abstract

An asymmetric 11-step synthesis of the polyoxygenated cyclohexene natural product kweichowenol A from the traditional Chinese medicinal herb Uvaria kweichowesis is reported. The oxygenation pattern was installed on a linear precursor by exploiting the acyclic stereocontrol of the Kiyooka aldol reaction, as well as Cram chelate-controlled Grignard reactions. Ring-closing metathesis and a selective benzoylation then gave the natural product.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 0936-5214
• Sprache: Englisch