Synthesis of acremines A, B and F and studies on the bisacremines

Winter, Nils und Trauner, Dirk (2019): Synthesis of acremines A, B and F and studies on the bisacremines. In: Beilstein Journal of Organic Chemistry, Bd. 15: S. 2271-2276

Abstract

The acremines are a family of meroterpenoids isolated from fungi of the genus Acremonium. Here, we present the asymmetric total synthesis of acremine F which hinges on a modestly enantioselective dihydroxylation and a subsequent kinetic resolution via a highly selective asymmetric reduction. Chemoselective oxidation of acremine F gave access to acremines A and B. The dimerization of acremine F to bisacremine E was investigated but could not be achieved, shedding light on the formation of the acremine dimers in nature.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Chemie und Pharmazie > Department Chemie
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie
• ISSN: 1860-5397
• Sprache: Englisch