The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy

Moschovakis, Georgios L.; Bubke, Anja; Friedrichsen, Michaela; Ristenpart, Jasmin; Back, Jaap Willem; Falk, Christine S.; Kremmer, Elisabeth und Foerster, Reinhold (2019): The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy. In: Cellular & Molecular Immunology, Bd. 16, Nr. 10: S. 791-799

Abstract

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs, thereby contributing to several aspects of adaptive immunity and immune tolerance. In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA). Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II (CII). Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody titers. Prophylactic and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression, respectively. Our data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Biologie > Department Biologie II
• Themengebiete: 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie
• ISSN: 1672-7681
• Sprache: Englisch