Large Animal Models of Diabetes

Ludwig, Barbara; Wolf, Eckhard; Schönmann, Uwe und Ludwig, Stefan (2020): Large Animal Models of Diabetes. In: King, Aileen J. F. (Hrsg.): Animal Models of Diabetes : Methods and Protocols. Methods in molecular biology, Bd. 2128. New York, NY: Springer. S. 115-134

Abstract

Safe and reliable large animal diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents but is often critiqued in higher animals due to reduced efficacy, relevant side effects, and inadequate mortality rate. In this chapter, we aim to describe both pharmacological and surgical approaches for reproducible and safe diabetes models in minipigs and primates. In addition, genetically modified pig models for diabetes research are described.

• Dokumententyp: Buchbeitrag
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISBN: 978-1-0716-0384-0 ; 978-1-0716-0385-7
• Ort: New York, NY
• Sprache: Englisch