Endomembrane trafficking pathways in Toxoplasma

Besteiro, Sébastien; Klinger, Christen M.; Meissner, Markus und Carruthers, Vern B. (2020): Endomembrane trafficking pathways in Toxoplasma. In: Weiss, Louis M. und Kim, Kami (Hrsg.): Toxoplasma gondii. 3. edition. Amsterdam [u.a.]: Elsevier. S. 705-741

Abstract

Toxoplasma gondii has an elaborate system of endomembranous pathways through which proteins and lipids traffic to their resident destinations. Whereas early studies suggested a link between endosomal compartments and the biogenesis of apical secretory organelles, recent work has validated that secretory proteins obligately transit through sections of the parasite endolysosomal system. Recent studies have also identified a terminal degradative compartment within the T. gondii endolysosomal system in addition to defining a role for this compartment in the turnover of host and parasite material delivered via endocytosis or autophagy. Together these advances suggest that the parasite not only has repurposed its endolysosomal system for exocytic traffic but also has retained its canonical degradative function. This chapter will integrate current knowledge of how secretory, endocytic, and autophagic material trafficks through the Toxoplasma endolysosomal system along with highlighting areas that remain poorly understood and in need of future interrogation.

• Dokumententyp: Buchbeitrag
• Keywords: Autophagy; endocytosis; endosome; lysosome; secretory; trafficking
• Fakultät: Tiermedizin > Veterinärwissenschaftliches Department > Lehrstuhl für Vergleichende Tropenmedizin und Parasitologie
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISBN: 978-0-12-815041-2
• Ort: Amsterdam [u.a.]
• Sprache: Englisch