Identification of KIF23 as a prognostic signature for ovarian cancer based on large-scale sampling and clinical validation

Hu, Yuexin; Zheng, Mingjun; Wang, Caixia; Wang, Shuang; Gou, Rui; Liu, Ouxuan; Li, Xiao; Liu, Juanjuan und Lin, Bei (2020): Identification of KIF23 as a prognostic signature for ovarian cancer based on large-scale sampling and clinical validation. In: American Journal of Translational Research, Bd. 12, Nr. 9: S. 4955-4976

Abstract

The purpose of this study is to explore the expression and clinical significance of KIF23 in ovarian cancer (OV) and identify potential targets for clinical treatment. Oncomine, GEO, and TCGA databases were used to analysis the expression of KIF23 in OV. The prognostic value of KIF23 gene was analyzed by the Kaplan-Meier plotter database. The molecular mechanism of KIF23 activity was analyzed from the perspective of immunology, gene mutation, copy number variation (CNV). Finally, immunohistochemistry was conducted to validate the expression of KIF23, univariable and multivariate cox analysis were used to determine its relationship with clinical characteristics and OV prognosis. It showed that highly expressed KIF23 is an adverse independent prognostic biomarker for OV patients. Genomics analysis showed that KIF23 expression was associated with mutations such as FLG2 and TTN, and was significantly enriched in DNA replication and the cell cycle tumor-related signaling pathways. Immunology analysis showed that KIF23 is closely related to the immune infiltration. KIF23 can not only performed as a prognosis signature in OV but also as a target of immune molecular therapeutics.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1943-8141
• Sprache: Englisch