Robustness of single-isocenter multiple-metastasis stereotactic radiosurgery end-to-end testing across institutions

Saenz, Daniel; Papanikolaou, Niko; Zoros, Emmanouil; Pappas, Evangelos; Reiner, Michael; Chew, Lip Teck; Lim, Hooi Yin; Hancock, Sam; Nebelsky, Alex; Njeh, Christopher und Anagnostopoulos, Georgios (2020): Robustness of single-isocenter multiple-metastasis stereotactic radiosurgery end-to-end testing across institutions. In: Journal of Radiosurgery and Sbrt, Bd. 7, Nr. 3: S. 223-232

Abstract

The accuracy of stereotactic radiosurgery (SRS) to multiple metastases with a single-isocenter using high definition dynamic radiosurgery (HDRS) was evaluated across institutions. An SRS plan was delivered at six HDRS-capable institutions to an anthropomorphic phantom consisting of point, film, and 3D-gel dosimeters. Direct dose comparison and gamma analysis were used to evaluate the accuracy. Point measurements averaged across institutions were within 1.2 +/- 0.5%. The average gamma passing rate in the film was 96.6 +/- 2.2% (3%/2 mm). For targets within 4 cm of the isocenter, the 3D dosimetric gel gamma passing rate averaged across institutions was >90% (3%/2 mm). The targeting accuracy of high definition dynamic radiosurgery assessed by geometrical offset of the center of dose distributions across multiple institutions in this study was within 1 mm for targets within 4 cm of isocenter. Across variations in clinical practice, comparable dosimetry and localization is possible with this treatment planning and delivery technique.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 2156-4639
• Sprache: Englisch