Abstract
Wolf's isotopic response describes the eruption of a secondary, pathogenically independent skin disease within the borders of a primary, already healed skin disease. The exact mechanism is unknown, but the restriction to diseases with a known T-cell component in the pathogenesis suggests an involvement of persistent local immune activation. We report the case of an 87-year-old woman who developed bullous pemphigoid lesions within the boundaries of a previous, already healed herpes zoster C7-C8, which had been diagnosed clinically and treated 2 months previously. Histopathological examination revealed subepidermal blisters, and indirect immunofluorescence showed IgG antibodies against the basal membrane zone. Both BP 180 and BP 230 enzyme-linked immunoassays (ELISAs) were positive. Based on these findings, we diagnosed a bullous pemphigoid arising on the site of the already healed herpes zoster, linked by an isotopic response.
Item Type: | Journal article |
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Faculties: | Medicine |
Subjects: | 600 Technology > 610 Medicine and health |
ISSN: | 0017-8470 |
Language: | German |
Item ID: | 85064 |
Date Deposited: | 25. Jan 2022, 09:13 |
Last Modified: | 25. Jan 2022, 09:13 |