Diagnose und Therapie der Zöliakie im Kindesalter. Aktualisierung anlässlich der neuen ESPGHAN-Leitlinien 2020

Werkstetter, Katharina und Koletzko, Sibylle (2020): Diagnose und Therapie der Zöliakie im Kindesalter. Aktualisierung anlässlich der neuen ESPGHAN-Leitlinien 2020. In: Monatsschrift Kinderheilkunde, Bd. 168, Nr. 5: S. 457-470

Abstract

Celiac disease is an immune-mediated systemic disorder with enteropathy, which is triggered by the grain protein gluten in genetically predisposed individuals. Untreated it can lead to nutrient deficiencies, impaired growth, osteoporosis, and other long-term complications. The prevalence in Germany is relatively high (ca. 1.0%) and can reach up to 15% in risk groups. While the classical gastrointestinal manifestations with chronic diarrhea, malabsorption syndrome and failure to thrive only occur in a minority of affected patients, most children and adults with celiac disease show no or only unspecific symptoms, such as constipation or extraintestinal signs, e.g. iron deficiency anemia and elevated liver enzymes. If celiac specific antibodies are positive the patient should be referred to a pediatric gastroenterologist for further confirmation of the diagnosis. The only available but extremely effective treatment is still a life-long strict gluten-free diet.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0026-9298
• Sprache: Deutsch