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Hufnagel, M.; Simon, A.; Trapp, S.; Liese, J.; Reinke, S.; Klein, W.; Parlowsky, T.; Pfeil, J.; Renk, H.; Berner, R.; Hübner, J.; Kummer, S. und Tillmann, R. (2020): Antibiotische Standardtherapie häufiger Infektionskrankheiten in der ambulanten Pädiatrie. Empfehlungen der Arbeitsgemeinschaft Antibiotic Stewardship ambulante Pädiatrie (ABSaP) der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI), des Berufsverbandes der Kinder- und Jugendärzte (BVKJ) und der Bielefelder Initiative AnTiB. In: Monatsschrift Kinderheilkunde, Bd. 169, Nr. 3: S. 258-265

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Abstract

Background: The increasing prevalence of antibiotic resistance together with the lack of development of new antibiotics require that antibiotics be prescribed rationally and according to well-established guidelines. This is especially relevant for outpatient settings as this is where 85% of all antibiotics are prescribed. Per capita, infants and young children are prescribed antibiotics at the highest rates. For this reason, they represent a natural target for antibiotic stewardship (ABS) programs. Objective: The ABS guidelines are often long and difficult to read. The working group for antibiotic stewardship in outpatient pediatrics has developed short and practical recommendations for standard antibiotic treatment of common pediatric infectious diseases in outpatient settings. Material and methods: These recommendations are based on well-established guidelines for rational antibiotic treatment and have been formulated through a consensus process by members of this working group. Input from the Professional Association of Pediatric and Adolescent Physicians (BVKJ) and the German Society for Pediatric Infectious Diseases (DGPI) were also incorporated into the recommendations. Results: Concise recommendations for standard antibiotic treatment of the most frequent pediatric infections of the upper and lower respiratory tracts, urinary tract, skin and eyes, in addition to surgical infections. Conclusion The goal of these recommendations is a reduction and improvement in the quality of antibiotic prescription in outpatient pediatrics. The unnecessary use of antibiotic treatment should be avoided or stopped as soon as possible. In situations where the bacterial origin of an infection is uncertain and where risk factors for severe bacterial infections are absent, no antibiotics should be prescribed. Instead, a clinical follow-up should be organized at short notice (watch and wait strategy). If antibiotics are in fact needed they should be prescribed for as short a time as possible and the spectrum should be as narrow as possible. References regarding length of treatment and choice of antibiotics are included in the recommendations provided. Topical antibiotics, cephalosporins and azithromycin should be avoided, because their use is associated with an increased risk of developing antibiotic resistance. In their stead, local disinfectants and penicillin-based antibiotics should be preferentially prescribed. In order to promote broad acceptance and use of the recommended guidelines and to reduce conflicts resulting from the variability of prescribing behavior, users are encouraged to adapt the recommendations by means of a local, intersectoral consensus process.

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