A novel mechanism of ACE inhibition-associated enhanced platelet reactivity: disproof of the ARB-MI paradox?

Helten, Carolin; Mourikis, Philipp; Dannenberg, Lisa; M'Pembele, Rene; Trojovsky, Kajetan; Ayhan, Aysel; Kohlmorgen, Christina; Grandoch, Maria; Levkau, Bodo; Veulemans, Verena; Petzold, Tobias; Hohlfeld, Thomas; Kelm, Malte; Zeus, Tobias und Polzin, Amin (2020): A novel mechanism of ACE inhibition-associated enhanced platelet reactivity: disproof of the ARB-MI paradox? In: European Journal of Clinical Pharmacology, Bd. 76, Nr. 9: S. 1245-1251

Abstract

Purpose: ACE inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are important drugs in cardiovascular disease. However, little is known about which of these drug class is to be preferred. First analyses show that the blockade of the renin-angiotensin-aldosterone system (RAAS) influences platelet reactivity. Therefore, we evaluated the effects of ACEI and ARB on platelet reactivity and thrombin generation. Methods We conducted a time series analysis in 34 patients. We performed light transmission aggregometry (LTA) to evaluate platelet reactivity. Results are given as maximum of aggregation (MoA). Thrombin generation was measured as endogenous thrombin potential (ETP) via calibrated automated thrombogram. Flow cytometry was used to analyze protease-activated receptor (PAR)-1 expression. Results ACEI treatment significantly increased platelet reactivity already 4 h after initiation of treatment (prior vs. 4 h post ACEI: MoA 41.9 +/- 16.2% vs. 55.2 +/- 16.7%;p = 0.003). After switching from ACEI to ARB treatment, platelet reactivity decreased significantly (3 months after switching: MoA 34.7 +/- 20.9%;p = 0.03). ACEI reduced endogenous thrombin potential significantly from before to 3 months after ACEI (ETP 1527 +/- 437 nM x min vs. 1088 +/- 631 nM x min;p = 0.025). Platelet thrombin receptor (PAR1) expression increased from 37.38 +/- 10.97% before to 49.53 +/- 6.04% after ACEI treatment (p = 0.036). Conclusion ACEI enhanced platelet reactivity. This can be reversed by changing to ARB. The mechanism behind RAAS influencing platelet function seems to be associated with PAR-1 expression.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0031-6970
• Sprache: Englisch