Head-down tilt bed rest with or without artificial gravity is not associated with motor unit remodeling

Attias, Julia; Grassi, Andrea; Bosutti, Alessandra; Ganse, Bergita; Degens, Hans und Drey, Michael (2020): Head-down tilt bed rest with or without artificial gravity is not associated with motor unit remodeling. In: European Journal of Applied Physiology, Bd. 120, Nr. 11: S. 2407-2415

Abstract

Purpose: The objective of this study was to assess whether artificial gravity attenuates any long-duration head-down 6(0)bed rest (HDBR)-induced alterations in motor unit (MU) properties. Methods Twenty-four healthy participants (16 men;8 women;26-54 years) underwent 60-day HDBR with (n = 16) or without (n = 8) 30 min artificial gravity daily induced by whole-body centrifugation. Compound muscle action potential (CMAP), MU number (MUNIX) and MU size (MUSIX) were estimated using the method of Motor Unit Number Index in the Abductor digiti minimi and tibialis anterior muscles 5 days before (BDC-5), and during day 4 (HDT4) and 59 (HDT59) of HDBR. Results The CMAP, MUNIX, and MUSIX at baseline did not change significantly in either muscle, irrespective of the intervention (p > 0.05). Across groups, there were no significant differences in any variable during HDBR, compared to BDC-5. Conclusion Sixty days of HDBR with or without artificial gravity does not induce alterations in motor unit number and size in the ADM or TA muscles in healthy individuals.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 1439-6319
• Sprache: Englisch