Grundlagen der Oligometastasierung und Stellenwert der Lokaltherapie

Ricke, J.; Guckenberger, M. und Grützmann, R. (2020): Grundlagen der Oligometastasierung und Stellenwert der Lokaltherapie. In: Onkologe, Bd. 26, Nr. 9: S. 776-781

Abstract

A distinction has traditionally been made in oncology between locally limited and systemically metastasized disease stages, in which local therapies pursued a curative or palliative goal. The term oligometastasis describes a vaguely defined intermediate stage in which randomized studies have demonstrated survival benefits of selected patient groups by using local ablative techniques. Currently, oligometastasis is defined by a limited number of metastases and affected organ systems independent of the tumor entity. Classical empirical evidence of the biological aggressiveness of metastasized tumors, such as disease-free interval or response to chemotherapy is not found in current recommendations. The biological Background: of a limited metastatic capacity is insufficiently understood as is the detection by biomarkers or gene expression profiles in order to be able to make an even more precise patient selection for a local therapeutic approach in addition to an optimal systemic therapy.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0947-8965
• Sprache: Deutsch