Abstract
Background: Current findings based on molecular approaches suggest an impact of the intestinal microbiome on the pathogenesis, diagnosis and therapy response of colorectal cancer (CRC) and its precancerous lesions. Numberless associations between mucosal and fecal bacterial signatures and phenotypic changes of the colorectal mucosa also underline the role of commensals in colorectal carcinogenesis. New noninvasive microbiome analyses demonstrated high diagnostic reliability for the presence of (pre-)cancerous conditions and for the evaluation of the localization of the primary tumor in the gastrointestinal tract. Unfavorable microbiome compositions affect the efficacy of classical chemotherapeutic agents and modulate the extent of drug-induced adverse reactions. Defined bacterial communities seem to improve response to treatment with checkpoint inhibitors. Methods: Based on a selective literature search we focused on current findings regarding the role of microbiota in diagnosis, therapy and carcinogenesis of CRC. Results: and conclusions: Associations between intestinal bacterial communities and CRC suggest a pivotal role of microbial members on the colorectal carcinogenesis. Preliminary data from trials on the use of microbial signatures in the noninvasive diagnosis of neoplastic colorectal lesions suggest a potential role in the future. Data from malignancies other than CRC that have shown a positive impact of the microbiome on the effect and side effects of checkpoint inhibitors have yet to be verified for CRC.
| Dokumententyp: | Zeitschriftenartikel |
|---|---|
| Fakultät: | Medizin |
| Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| ISSN: | 0947-8965 |
| Sprache: | Deutsch |
| Dokumenten ID: | 85365 |
| Datum der Veröffentlichung auf Open Access LMU: | 25. Jan. 2022, 09:14 |
| Letzte Änderungen: | 25. Jan. 2022, 09:14 |
- Dokument bearbeiten
