Abstract
In the past 25 years neuroimaging studies have made a significant contribution to further the understanding of the pathophysiology of juvenile myoclonic epilepsy (JME). This article summarizes the key results of these studies and discusses their meaning in the context of genetic alterations and brain development in JME. In summary, JME is a complex neurodevelopmental disease resulting in multiple structural and functional alterations of cortical and subcortical structures. These alterations ultimately lead to a pathologically increased corticocortical connectivity, impaired cortical inhibition and impaired thalamocortical feedback regulation. Many of these alterations affect the frontocentral motor system but more recent studies have also shown significant alterations in other brain regions.
Dokumententyp: | Zeitschriftenartikel |
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Fakultät: | Medizin |
Themengebiete: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
ISSN: | 1617-6782 |
Sprache: | Deutsch |
Dokumenten ID: | 85392 |
Datum der Veröffentlichung auf Open Access LMU: | 25. Jan. 2022, 09:14 |
Letzte Änderungen: | 25. Jan. 2022, 09:14 |