Left-ventricular innervation assessed by I-123-SPECT/CT is associated with cardiac events in inherited arrhythmia syndromes

Siebermair, Johannes; Lehner, Sebastian; Sattler, Stefan M.; Rizas, Konstantinos D.; Beckmann, Britt-Maria; Becker, Alexander; Schiller, Julia; Metz, Corona; Zacherl, Mathias; Vonderlin, Nadine; Rassaf, Tienush; Dobrev, Dobromir; Rischpler, Christoph; Kääb, Stefan; Hacker, Marcus; Todica, Andrei und Wakili, Reza (2020): Left-ventricular innervation assessed by I-123-SPECT/CT is associated with cardiac events in inherited arrhythmia syndromes. In: International Journal of Cardiology, Bd. 312: S. 129-135

Abstract

Aims: Impaired myocardial sympathetic innervation assessed by (123)Iodine-Metaiodobenzylguanidine (I-123-MIBG) scintigraphy is associated with cardiac events. Since regional disparities of structural abnormalities are common in inherited arrhythmia syndromes (iAS), a chamber-specific innervation assessment of the right (RV) and left ventricle (LV) could provide important insights for a patient-individual therapy. Aim of this studywas to evaluate chamber-specific patterns of autonomic innervation by Single-photon emission computed tomography/computed tomography (SPECT/CT) in patients with iAS with respect to clinical outcome regarding cardiac events. Methods and results: We assessed ventricular sympathetic innervation (LV, RV and planar heart/mediastinumratios, andwashout-rates) by I-123-MIBG-SPECT/CT in 48 patients (arrhythmogenic right ventricular cardiomyopathy [ARVC], n = 26;laminopathy, n = 8;idiopathic ventricular fibrillation [iVF], n = 14) in relation to a composite clinical endpoint (ventricular arrhythmia;cardiac death;cardiac hospitalization). RV tracer uptake was lower in patientswith ARVC than in laminopathy and iVF patients (1.7 +/- 0.4 vs. 2.1 +/- 0.7 and 2.1 +/- 0.5, respectively). Over amedian follow-up of 2.2 years, the combined endpointwasmet in 18 patients (n= 12 ventricular tachyarrhythmias, n= 5 hospitalizations, n= 1 death). LV, but not RV H/M ratio was associated with the combined endpoint (hazard-ratio 2.82 [1.30-6.10], p < 0.01). After adjustment for LV and RV function, LV H/M-ratio still remained a significant predictor for cardiac events (hazard-ratio 2.79 [1.06-7.35], p = 0.04). Conclusion: We demonstrated that chamber-specific (123)MIBG-SPECT/CT imaging is feasible and that reduced LV sympathetic innervation was associated with worse outcome in iAS. These findings provide novel insights into the potential role of regional autonomic nervous system heterogeneity for the evolution of life-threatening cardiac events in iAS. (c) 2020 Published by Elsevier B.V.

• Dokumententyp: Zeitschriftenartikel
• Fakultät: Medizin
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• ISSN: 0167-5273
• Sprache: Englisch